Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12879-018-3211-9
Title: Correlation of clinical illness with viremia in Zika virus disease during an outbreak in Singapore
Authors: Ng, D.H.L
Ho, H.J
Chow, A 
Wong, J
Kyaw, W.M
Tan, A
Chia, P.Y
Choy, C.Y
Tan, G
Yeo, T.W
Leo, Y.S 
Keywords: abdominal pain
adult
arthralgia
Article
clinical article
clinical feature
cohort analysis
conjunctivitis
controlled study
crackle
diarrhea
disease association
disease duration
disorientation
epidemic
female
fever
headache
hospital admission
human
hypokalemia
jaundice
leukopenia
longitudinal study
lymphadenopathy
male
myalgia
nausea and vomiting
pharyngitis
polymerase chain reaction
prospective study
rash
Singapore
thrombocytopenia
viremia
wheezing
Zika fever
blood
epidemiology
middle aged
pathophysiology
viremia
virology
Zika fever
Zika virus
Adult
Cohort Studies
Disease Outbreaks
Exanthema
Female
Fever
Humans
Longitudinal Studies
Male
Middle Aged
Polymerase Chain Reaction
Prospective Studies
Singapore
Viremia
Zika Virus
Zika Virus Infection
Issue Date: 2018
Citation: Ng, D.H.L, Ho, H.J, Chow, A, Wong, J, Kyaw, W.M, Tan, A, Chia, P.Y, Choy, C.Y, Tan, G, Yeo, T.W, Leo, Y.S (2018). Correlation of clinical illness with viremia in Zika virus disease during an outbreak in Singapore. BMC Infectious Diseases 18 (1) : 301. ScholarBank@NUS Repository. https://doi.org/10.1186/s12879-018-3211-9
Rights: Attribution 4.0 International
Abstract: Background: The first autochthonous Zika virus (ZIKV) outbreak in Singapore was detected in August 2016. We report an analysis of the correlation of clinical illness with viremia and laboratory parameters in this Asian cohort. Methods: We conducted a prospective longitudinal cohort study of patients with a positive blood ZIKV polymerase chain reaction (PCR) result who were admitted to Tan Tock Seng Hospital, Singapore, for isolation and management. Results: We included 40 patients in our study. Rash was present in all patients, while 80% (32/40) had fever, 62.5% (25/40) myalgia, 60% (24/40) conjunctivitis and 38% (15/40) arthralgia. The median duration of viremia was 3.5 days (IQR: 3-5 days). Patients with viremia of ?4 days were more likely to have prolonged fever compared to those with viremia of less than 4 days (95% versus 63%, p = 0.01), but had no significant correlation with other clinical signs and symptoms, or laboratory investigations. However, 21 patients (53%) had hypokalemia despite the absence of gastrointestinal symptoms. Conclusion: Although fever correlated with duration of viremia, 30% of patients remained viremic despite defervescence. Laboratory abnormalities such as leukopenia or thrombocytopenia were not prominent in this cohort but about half the patients were noted to have hypokalemia. © 2018 The Author(s).
Source Title: BMC Infectious Diseases
URI: https://scholarbank.nus.edu.sg/handle/10635/181192
ISSN: 14712334
DOI: 10.1186/s12879-018-3211-9
Rights: Attribution 4.0 International
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