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https://doi.org/10.1128/JVI.00697-06
Title: | Prevalence and genetic diversity of coronaviruses in bats from China | Authors: | Tang, X.C Zhang, J.X Zhang, S.Y Wang, P Fan, X.H Li, L.F Li, G Dong, B.Q Liu, W Cheung, C.L Xu, K.M Song, W.J Vijaykrishna, D Poon, L.L.M Peiris, J.S.M Smith, G.J.D Chen, H Guan, Y |
Keywords: | envelope protein membrane protein nucleoprotein nucleotide RNA directed RNA polymerase RNA helicase virus RNA amino terminal sequence article bat carboxy terminal sequence China Coronavirus genetic variability genome analysis nonhuman nucleotide sequence open reading frame phylogeny prevalence priority journal reverse transcription polymerase chain reaction sequence homology unindexed sequence virus genome virus transmission Animals China Chiroptera Coronavirus Evolution, Molecular Genome, Viral Molecular Sequence Data Phylogeny Prevalence RNA, Viral Sequence Analysis, DNA Variation (Genetics) Viral Proteins Animalia Coronavirus |
Issue Date: | 2006 | Citation: | Tang, X.C, Zhang, J.X, Zhang, S.Y, Wang, P, Fan, X.H, Li, L.F, Li, G, Dong, B.Q, Liu, W, Cheung, C.L, Xu, K.M, Song, W.J, Vijaykrishna, D, Poon, L.L.M, Peiris, J.S.M, Smith, G.J.D, Chen, H, Guan, Y (2006). Prevalence and genetic diversity of coronaviruses in bats from China. Journal of Virology 80 (15) : 7481-7490. ScholarBank@NUS Repository. https://doi.org/10.1128/JVI.00697-06 | Rights: | Attribution 4.0 International | Abstract: | Coronaviruses can infect a variety of animals including poultry, livestock, and humans and are currently classified into three groups. The interspecies transmissions of coronaviruses between different hosts form a complex ecosystem of which little is known. The outbreak of severe acute respiratory syndrome (SARS) and the recent identification of new coronaviruses have highlighted the necessity for further investigation of coronavirus ecology, in particular the role of bats and other wild animals. In this study, we sampled bat populations in 15 provinces of China and reveal that approximately 6.5% of the bats, from diverse species distributed throughout the region, harbor coronaviruses. Full genomes of four coronavirues from bats were sequenced and analyzed. Phylogenetic analyses of the spike, envelope, membrane, and nucleoprotein structural proteins and the two conserved replicase domains, putative RNA-dependent RNA polymerase and RNA helicase, revealed that bat coronaviruses cluster in three different groups: group 1, another group that includes all SARS and SARS-like coronaviruses (putative group 4), and an independent bat coronavirus group (putative group 5). Further genetic analyses snowed that different species of bats maintain coronaviruses from different groups and that a single bat species from different geographic locations supports similar coronaviruses. Thus, the findings of this study suggest that bats may play an integral role in the ecology and evolution of coronaviruses. Copyright © 2006, American Society for Microbiology. All Rights Reserved. | Source Title: | Journal of Virology | URI: | https://scholarbank.nus.edu.sg/handle/10635/181057 | ISSN: | 0022-538X | DOI: | 10.1128/JVI.00697-06 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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