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https://doi.org/10.3389/fimmu.2015.00486
Title: | Ontogeny of tissue-resident macrophages | Authors: | Hoeffel, G Ginhoux, F |
Keywords: | CD16 antigen CD32 antigen chemokine receptor CCR2 chemokine receptor CX3CR1 colony stimulating factor receptor fibrinogen receptor monocyte chemotactic protein 1 adult cell differentiation cell proliferation densitometry fetus gene mapping hematopoiesis hematopoietic stem cell human Langerhans cell lymphoid progenitor cell macrophage megakaryocyte mesonephros microglia monocyte macrophage precursor cell natural killer cell nonhuman ontogeny Review yolk sac |
Issue Date: | 2015 | Citation: | Hoeffel, G, Ginhoux, F (2015). Ontogeny of tissue-resident macrophages. Frontiers in Immunology 6 (SEP) : 486. ScholarBank@NUS Repository. https://doi.org/10.3389/fimmu.2015.00486 | Rights: | Attribution 4.0 International | Abstract: | The origin of tissue-resident macrophages, crucial for homeostasis and immunity, has remained controversial until recently. Originally described as part of the mononuclear phagocyte system, macrophages were long thought to derive solely from adult blood circulating monocytes. However, accumulating evidence now shows that certain macrophage populations are in fact independent from monocyte and even from adult bone marrow hematopoiesis. These tissue-resident macrophages derive from sequential seeding of tissues by two precursors during embryonic development. Primitive macrophages generated in the yolk sac (YS) from early erythro-myeloid progenitors (EMPs), independently of the transcription factor c-Myb and bypassing monocytic intermediates, first give rise to microglia. Later, fetal monocytes, generated from c-Myb+ EMPs that initially seed the fetal liver (FL), then give rise to the majority of other adult macrophages. Thus, hematopoietic stem cell-independent embryonic precursors transiently present in the YS and the FL give rise to long-lasting self-renewing macrophage populations. © 2015 Hoeffel and Ginhoux. | Source Title: | Frontiers in Immunology | URI: | https://scholarbank.nus.edu.sg/handle/10635/180933 | ISSN: | 16643224 | DOI: | 10.3389/fimmu.2015.00486 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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