Please use this identifier to cite or link to this item: https://doi.org/10.1155/2015/457123
Title: Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease
Authors: Yong, K.-L
Chng, C.L 
Htoon, H.M 
Lim, L.H 
Seah, L.L 
Keywords: glucose
liver enzyme
methotrexate
methylprednisolone
potassium
adjuvant chemoradiotherapy
adjuvant therapy
adult
Article
bradycardia
chest tightness
clinical article
color vision
combination chemotherapy
controlled study
decompression surgery
diastolic blood pressure
dose response
drug efficacy
drug pulse therapy
drug safety
dyspnea
ECG abnormality
endocrine ophthalmopathy
female
fever
flushing
gastritis
glucose blood level
headache
heart palpitation
heart rate
human
hypertension
hyperthyroidism
insomnia
male
monotherapy
multiple cycle treatment
potassium blood level
priority journal
rash
retrospective study
side effect
slit lamp
systolic blood pressure
tachycardia
thyroid function test
treatment duration
treatment indication
treatment withdrawal
urticaria
urticarial rash
visual acuity
vital sign
Issue Date: 2015
Citation: Yong, K.-L, Chng, C.L, Htoon, H.M, Lim, L.H, Seah, L.L (2015). Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease. International Journal of Endocrinology 2015 : 457123. ScholarBank@NUS Repository. https://doi.org/10.1155/2015/457123
Rights: Attribution 4.0 International
Abstract: Objective. To analyze changes in vital signs (heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP)) during and after intravenous methylprednisolone (IVMP) and any other adverse effects. Methods. Retrospective review of charts of patients who received IVMP as treatment regime for thyroid eye disease. All subjects had vital signs charted during and after infusions. Results. This study included 38 subjects and a total of 242 infusions administered. IVMP resulted in a small but significant percentage drop in mean SBP at 30 min (p < 0.001) and 60 min (p = 0.03) but no difference at 90 min. There was also small but significant percentage drop in mean DBP and HR (DBP: p < 0.001 for 30 min, p = 0.001 for 60 min, and p = 0.02 for 90 min and HR: p < 0.001 for 30 min, 60 min, and 90 min). There were no cumulative effects on change of blood pressure or HR. There were 6 episodes of bradycardia (2.5%) and 12 episodes of moderate to severe hypertension (5%). No significant cardiovascular or hepatic toxicity was found. Conclusion. IVMP is relatively safe and efficacious. IVMP demonstrated mild and noncumulative effects on vital signs. Severe hypertension may occur in susceptible individuals such as those with underlying hypertension and uncontrolled thyroid dysfunction, whereas bradycardia may be more likely in those on beta-blockers. © 2015 Kai-Ling Yong et al.
Source Title: International Journal of Endocrinology
URI: https://scholarbank.nus.edu.sg/handle/10635/180924
ISSN: 16878337
DOI: 10.1155/2015/457123
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1155_2015_457123.pdf1.35 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

3
checked on May 13, 2022

Page view(s)

131
checked on May 12, 2022

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons