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https://doi.org/10.1038/srep09290
Title: | Limbus- Versus Fornix-Based Trabeculectomy for Open-Angle Glaucoma Eyes with Prior Ocular Surgery: The Collaborative Bleb-Related Infection Incidence and Treatment Study | Authors: | Yokota, S Takihara, Y Inatani, M |
Keywords: | aged clinical trial female follow up Glaucoma, Open-Angle human intraocular pressure Kaplan Meier method male middle aged mortality multicenter study procedures trabeculectomy treatment outcome very elderly Aged Aged, 80 and over Female Follow-Up Studies Glaucoma, Open-Angle Humans Intraocular Pressure Kaplan-Meier Estimate Male Middle Aged Trabeculectomy Treatment Outcome |
Issue Date: | 2015 | Publisher: | Nature Publishing Group | Citation: | Yokota, S, Takihara, Y, Inatani, M (2015). Limbus- Versus Fornix-Based Trabeculectomy for Open-Angle Glaucoma Eyes with Prior Ocular Surgery: The Collaborative Bleb-Related Infection Incidence and Treatment Study. Scientific Reports 5 : 9290. ScholarBank@NUS Repository. https://doi.org/10.1038/srep09290 | Rights: | Attribution 4.0 International | Abstract: | We compared the surgical successes of limbus- and fornix-based trabeculectomies in open-angle glaucoma (OAG) eyes that had prior ocular surgery in the Collaborative Bleb-Related Infection Incidence and Treatment Study (CBIITS), Japan. From the 1,098 glaucoma eyes in 34 clinical centers in CBIITS, 195 OAG eyes that had undergone previous trabeculectomy and/or lens extraction were included. Limbus- or fornix-based trabeculectomy with mitomycin C were performed. Surgical failure (IOP ? 21, 18, or 15 mmHg for criterion A, B or C, respectively; <20% decrease from baseline; reoperation for glaucoma; or loss of light perception vision) was counted. There were 106 and 89 eyes treated with limbus- and fornix-based trabeculectomies, respectively. At 3 years, IOP (mean ± SD) was 12.5 ± 5.9 and 14.1 ± 6.4 mmHg and the cumulative probabilities of failure during 3 years were 30.2% and 50.5% for criterion A, 40.3% and 57.4% for criterion B, and 57.9% and 65.8% for criterion C in the limbus- and the fornix-based group, respectively. Fornix-based incisions were associated with surgical failure in Cox-proportional multivariable analysis for criterion A [relative risk (RR) = 1.96], and B [RR = 1.60]. Limbus-based trabeculectomy had a higher probability of success in OAG eyes with prior ocular surgery. © 2015, Nature Publishing Group. All rights reserved. | Source Title: | Scientific Reports | URI: | https://scholarbank.nus.edu.sg/handle/10635/180477 | ISSN: | 2045-2322 | DOI: | 10.1038/srep09290 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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