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https://doi.org/10.1099/vir.0.068403-0
Title: | Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhea patients in Ho Chi Minh City, Vietnam | Authors: | My, P.V.T Rabaa, M.A Donato, C Cowley, D Phat, V.V Dung, T.T.N Anh, P.H Vinh, H Bryant, J.E Kellam, P Thwaites, G Woolhouse, M.E.J Kirkwood, C.D Baker, S |
Keywords: | vaccine Article Asia diarrhea disease surveillance gene sequence genetic reassortment genetic variability hospitalized child human Human rotavirus Viet Nam virus strain |
Issue Date: | 2014 | Publisher: | Microbiology Society | Citation: | My, P.V.T, Rabaa, M.A, Donato, C, Cowley, D, Phat, V.V, Dung, T.T.N, Anh, P.H, Vinh, H, Bryant, J.E, Kellam, P, Thwaites, G, Woolhouse, M.E.J, Kirkwood, C.D, Baker, S (2014). Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhea patients in Ho Chi Minh City, Vietnam. Journal of General Virology 95 : 2727-2733. ScholarBank@NUS Repository. https://doi.org/10.1099/vir.0.068403-0 | Rights: | Attribution 4.0 International | Abstract: | During a hospital-based diarrhoeal disease study conducted in Ho Chi Minh City, Vietnam from 2009 to 2010, we identified four symptomatic children infected with G26P[19] rotavirus (RV)-an atypical variant that has not previously been reported in human gastroenteritis. To determine the genetic structure and investigate the origin of this G26P[19] strain, the whole genome of a representative example was characterized, revealing a novel genome constellation: G26-P[19]-I5-R1-C1-M1-A8-N1-T1-E1-H1. The genome segments were most closely related to porcine (VP7, VP4, VP6 and NSP1) and Wa-like porcine RVs (VP1-3 and NSP2-5). We proposed that this G26P[19] strain was the product of zoonotic transmission coupled with one or more reassortment events occurring in human and/or animal reservoirs. The identification of such strains has potential implications for vaccine efficacy in south-east Asia, and outlines the utility of whole-genome sequencing for studying RV diversity and zoonotic potential during disease surveillance. © 2014 The Authors. | Source Title: | Journal of General Virology | URI: | https://scholarbank.nus.edu.sg/handle/10635/180131 | ISSN: | 0022-1317 | DOI: | 10.1099/vir.0.068403-0 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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