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Title: Preparation of HCPT-Loaded Nanoneedles with Pointed Ends for Highly Efficient Cancer Chemotherapy
Authors: Wu, S
Yang, X
Li, Y
Wu, H
Huang, Y
Xie, L
Zhang, Y
Hou, Z
Liu, X 
Keywords: Chemotherapy
Particle size
Ultrasonic applications
10 hydroxycamptothecin (HCPT)
Cellular internalization
Cellular uptake
Emulsion crystallization
High aspect ratio
Shape-dependent effects
Aspect ratio
Issue Date: 2016
Citation: Wu, S, Yang, X, Li, Y, Wu, H, Huang, Y, Xie, L, Zhang, Y, Hou, Z, Liu, X (2016). Preparation of HCPT-Loaded Nanoneedles with Pointed Ends for Highly Efficient Cancer Chemotherapy. Nanoscale Research Letters 11 (1) : 294. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: The high-aspect-ratio nanoparticles were proved to be internalized much more rapidly and efficiently by cancer cells than the nanoparticles with an equal aspect ratio. Herein, a kind of high-aspect ratio, pointed-end nanoneedles (NDs) with a high drug loading (15.04 %) and the prolonged drug release profile were fabricated with an anti-tumor drug—10-hydroxycamptothecin (HCPT)—via an ultrasound-assisted emulsion crystallization technique. It is surprising to see that the cellular internalization of NDs with an average length of 5 ?m and an aspect ratio of about 12:1 was even much faster and higher than that of nanorods with the same size and the nanospheres with a much smaller size of 150 nm. The results further validated that cellular internalization of the nanoparticles exhibited a strong shape-dependent effect, and cellular uptake may favor the particles with sharp ends as well as a high-aspect ratio instead of particle size. The NDs with enhanced cytotoxicity would lead to a promising sustained local drug delivery system for highly efficient anticancer therapy. More importantly, the fabrication of NDs opens a door to design new formulations of nanoneedle drug delivery systems for highly efficient cancer. © 2016, The Author(s).
Source Title: Nanoscale Research Letters
ISSN: 19317573
DOI: 10.1186/s11671-016-1491-9
Rights: Attribution 4.0 International
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