Please use this identifier to cite or link to this item:
https://doi.org/10.18632/oncotarget.15711
Title: | The effects of DLEU1 gene expression in Burkitt lymphoma (BL): Potential mechanism of chemoimmunotherapy resistance in BL | Authors: | Lee, S Luo, W Shah, T Yin, C O'Connell, T Chung, T.-H Perkins, S.L Miles, R.R Ayello, J Morris, E Harrison, L van de Ven, C Cairo, M.S |
Keywords: | cyclophosphamide rituximab transcription activator like effector nuclease animal experiment animal model animal tissue apoptosis Article Burkitt lymphoma cancer chemotherapy cancer immunotherapy cancer survival cell proliferation controlled study DLEU1 gene embryo female gene gene expression gene overexpression gene silencing human human cell mouse nonhuman tumor xenograft |
Issue Date: | 2017 | Citation: | Lee, S, Luo, W, Shah, T, Yin, C, O'Connell, T, Chung, T.-H, Perkins, S.L, Miles, R.R, Ayello, J, Morris, E, Harrison, L, van de Ven, C, Cairo, M.S (2017). The effects of DLEU1 gene expression in Burkitt lymphoma (BL): Potential mechanism of chemoimmunotherapy resistance in BL. Oncotarget 8 (17) : 27839-27853. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.15711 | Rights: | Attribution 4.0 International | Abstract: | Following a multivariant analysis we demonstrated that children and adolescents with Burkitt lymphoma (BL) and a 13q14.3 deletion have a significant decrease in event free survival (EFS) despite identical short intensive multi-agent chemotherapy. However, how this deletion in the 13q14.3 region is associated with a significant decrease in EFS in children and adolescents with BL is largely unknown. The gene Deleted in Lymphocytic Leukemia 1 (DLEU1) is located in the region of 13q14.3. Here, we report that DLEU1 expression is implicated in the regulation of BL programmed cell death, cell proliferation, and expression of apoptotic genes in transcription activatorlike effector nuclease (TALEN)s-induced DLEU1 knockdown and DLEU1 overexpressing BL cell lines. Furthermore, NSG mice xenografted with DLEU1 knockdown BL cells had significantly shortened survival (p < 0.05 and p < 0.005), whereas those xenografted with DLEU1 overexpressing BL cells had significantly improved survival (p < 0.05 and p < 0.0001), following treatment with rituximab and/or cyclophosphamide. These data suggest that DLEU1 may in part function as a tumor suppressor gene and confer chemoimmunotherapy resistance in children and adolescents with BL. | Source Title: | Oncotarget | URI: | https://scholarbank.nus.edu.sg/handle/10635/179885 | ISSN: | 19492553 | DOI: | 10.18632/oncotarget.15711 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_18632_oncotarget_15711.pdf | 3.64 MB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License