Please use this identifier to cite or link to this item:
https://doi.org/10.18632/oncotarget.14122
Title: | Genomic differences between black and white patients implicate a distinct immune response to papillary renal cell carcinoma | Authors: | Paulucci, D.J Sfakianos, J.P Skanderup, A.J Kan, K Tsao, C.K Galsky, M.D Ari Hakimi, A Badani, K.K |
Keywords: | B lymphocyte receptor defensin nucleotide binding oligomerization domain like receptor vasculotropin vasculotropin receptor Wnt protein adult age aged Article Black person body mass cancer immunotherapy cancer specific survival cancer staging Caucasian cohort analysis controlled study CRYBB2 gene female gene gene overexpression genetic correlation genetic difference human immune response immune system kidney carcinoma major clinical study male overall survival papillary carcinoma papillary renal cell carcinoma propensity score race race difference retrospective study RNA sequence sex difference signal transduction somatic mutation tumor immunology Wnt signaling pathway |
Issue Date: | 2017 | Publisher: | Impact Journals LLC | Citation: | Paulucci, D.J, Sfakianos, J.P, Skanderup, A.J, Kan, K, Tsao, C.K, Galsky, M.D, Ari Hakimi, A, Badani, K.K (2017). Genomic differences between black and white patients implicate a distinct immune response to papillary renal cell carcinoma. Oncotarget 8 (3) : 5196-5205. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.14122 | Rights: | Attribution 4.0 International | Abstract: | Significant disparities in survival, incidence and possibly response to current therapies exist between black and white patients with renal cell carcinoma (RCC). Recent genomic evidence to account for these disparities has been reported for clear cell RCC. However, racial disparities at the genomic level for papillary RCC (pRCC) which is a genetically distinct and less responsive histologic subtype of RCC have not been reported. Using The Cancer Genome Atlas (TCGA) data, the present study assessed gene-level expression, somatic mutation and pathway differences between 58 black and 58 white patients with pRCC propensity matched on age, gender and pathologic T stage. Distinct tumor biology with differential expression patterns were observed in black vs. white patients with pRCC. Specifically, significance analysis of microarrays was applied to TCGA gene expression data and identified 163 genes and 120 genes overexpressed in black and white patients, respectively (FDR q < 0.05). Gene Set Enrichment Analysis identified 62 gene sets enriched (p < 0.10) in blacks. Enrichment of immune immune system pathways were noted in black patients. These included the B cell receptor signaling pathway, the NOD-like receptor signaling pathway and genes involved in defensins. The VEGF pathway was also more significant in black patients. CRYBB2, a gene associated with the WNT pathway was overexpressed in Black patients. While our data requires validation, these findings suggest that race may have implications for distinct immune responses to cancer and that the use of immunotherapies, and VEGFR inhibitors to target these pathways may improve survival in black patients with advanced pRCC. | Source Title: | Oncotarget | URI: | https://scholarbank.nus.edu.sg/handle/10635/179770 | ISSN: | 1949-2553 | DOI: | 10.18632/oncotarget.14122 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_18632_oncotarget_14122.pdf | 2.3 MB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License