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https://doi.org/10.1128/AAC.02019-15
| Title: | In Vitro activities of ceftazidime-avibactam, aztreonam-avibactam, and a panel of older and contemporary antimicrobial agents against carbapenemase-producing gram-negative bacilli | Authors: | Vasoo, S Cunningham, S.A Cole, N.C Kohner, P.C Menon, S.R Krause, K.M Harris, K.A De, P.P Koh, T.H Patel, R |
Keywords: | amikacin avibactam aztreonam cefepime ceftazidime ceftriaxone ciprofloxacin colistin cotrimoxazole ertapenem fosfomycin gentamicin levofloxacin mecillinam meropenem metallo beta lactamase nitrofurantoin piperacillin plus tazobactam tigecycline tobramycin antiinfective agent avibactam avibactam, ceftazidime drug combination azabicyclo derivative aztreonam bacterial protein beta lactamase carbapenemase ceftazidime colistin drug combination fosfomycin minocycline tigecycline agar dilution antibiotic sensitivity Article bacterial strain bacterium isolate carbapenemase producing Enterobacteriaceae controlled study Escherichia coli extended spectrum beta lactamase producing Enterobacteriaceae Klebsiella pneumoniae minimum inhibitory concentration nonhuman priority journal Pseudomonas aeruginosa Staphylococcus aureus analogs and derivatives classification drug combination drug effects Enterobacteriaceae enzymology gene expression genetics growth, development and aging human metabolism microbial sensitivity test Anti-Bacterial Agents Azabicyclo Compounds Aztreonam Bacterial Proteins beta-Lactamases Ceftazidime Colistin Drug Combinations Enterobacteriaceae Fosfomycin Gene Expression Humans Microbial Sensitivity Tests Minocycline |
Issue Date: | 2015 | Publisher: | American Society for Microbiology | Citation: | Vasoo, S, Cunningham, S.A, Cole, N.C, Kohner, P.C, Menon, S.R, Krause, K.M, Harris, K.A, De, P.P, Koh, T.H, Patel, R (2015). In Vitro activities of ceftazidime-avibactam, aztreonam-avibactam, and a panel of older and contemporary antimicrobial agents against carbapenemase-producing gram-negative bacilli. Antimicrobial Agents and Chemotherapy 59 (12) : 7842-7846. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.02019-15 | Rights: | Attribution 4.0 International | Abstract: | Among 177 carbapenemase-producing Gram-negative bacilli (108 KPC, 32 NDM, 11 IMP, 8 OXA-48, 4 OXA-181, 2 OXA-232, 5 IMI, 4 VIM, and 3 SME producers), aztreonam-avibactam was active against all isolates except two NDM producers with elevated MICs of 8/4 and 16/4 mg/liter; ceftazidime-avibactam was active against all KPC-, IMI-, SME-, and most OXA-48 group-producing isolates (93%) but not metallo-?-lactamase producers. Among older and contemporary antimicrobials, the most active were colistin, tigecycline, and fosfomycin, with overall susceptibilities of 88%, 79%, and 78%, respectively. © 2015, American Society for Microbiology. All Rights Reserved. | Source Title: | Antimicrobial Agents and Chemotherapy | URI: | https://scholarbank.nus.edu.sg/handle/10635/179635 | ISSN: | 0066-4804 | DOI: | 10.1128/AAC.02019-15 | Rights: | Attribution 4.0 International |
| Appears in Collections: | Staff Publications Elements |
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