Please use this identifier to cite or link to this item: https://doi.org/10.1128/AAC.02019-15
Title: In Vitro activities of ceftazidime-avibactam, aztreonam-avibactam, and a panel of older and contemporary antimicrobial agents against carbapenemase-producing gram-negative bacilli
Authors: Vasoo, S
Cunningham, S.A
Cole, N.C
Kohner, P.C
Menon, S.R
Krause, K.M
Harris, K.A
De, P.P
Koh, T.H 
Patel, R
Keywords: amikacin
avibactam
aztreonam
cefepime
ceftazidime
ceftriaxone
ciprofloxacin
colistin
cotrimoxazole
ertapenem
fosfomycin
gentamicin
levofloxacin
mecillinam
meropenem
metallo beta lactamase
nitrofurantoin
piperacillin plus tazobactam
tigecycline
tobramycin
antiinfective agent
avibactam
avibactam, ceftazidime drug combination
azabicyclo derivative
aztreonam
bacterial protein
beta lactamase
carbapenemase
ceftazidime
colistin
drug combination
fosfomycin
minocycline
tigecycline
agar dilution
antibiotic sensitivity
Article
bacterial strain
bacterium isolate
carbapenemase producing Enterobacteriaceae
controlled study
Escherichia coli
extended spectrum beta lactamase producing Enterobacteriaceae
Klebsiella pneumoniae
minimum inhibitory concentration
nonhuman
priority journal
Pseudomonas aeruginosa
Staphylococcus aureus
analogs and derivatives
classification
drug combination
drug effects
Enterobacteriaceae
enzymology
gene expression
genetics
growth, development and aging
human
metabolism
microbial sensitivity test
Anti-Bacterial Agents
Azabicyclo Compounds
Aztreonam
Bacterial Proteins
beta-Lactamases
Ceftazidime
Colistin
Drug Combinations
Enterobacteriaceae
Fosfomycin
Gene Expression
Humans
Microbial Sensitivity Tests
Minocycline
Issue Date: 2015
Publisher: American Society for Microbiology
Citation: Vasoo, S, Cunningham, S.A, Cole, N.C, Kohner, P.C, Menon, S.R, Krause, K.M, Harris, K.A, De, P.P, Koh, T.H, Patel, R (2015). In Vitro activities of ceftazidime-avibactam, aztreonam-avibactam, and a panel of older and contemporary antimicrobial agents against carbapenemase-producing gram-negative bacilli. Antimicrobial Agents and Chemotherapy 59 (12) : 7842-7846. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.02019-15
Rights: Attribution 4.0 International
Abstract: Among 177 carbapenemase-producing Gram-negative bacilli (108 KPC, 32 NDM, 11 IMP, 8 OXA-48, 4 OXA-181, 2 OXA-232, 5 IMI, 4 VIM, and 3 SME producers), aztreonam-avibactam was active against all isolates except two NDM producers with elevated MICs of 8/4 and 16/4 mg/liter; ceftazidime-avibactam was active against all KPC-, IMI-, SME-, and most OXA-48 group-producing isolates (93%) but not metallo-?-lactamase producers. Among older and contemporary antimicrobials, the most active were colistin, tigecycline, and fosfomycin, with overall susceptibilities of 88%, 79%, and 78%, respectively. © 2015, American Society for Microbiology. All Rights Reserved.
Source Title: Antimicrobial Agents and Chemotherapy
URI: https://scholarbank.nus.edu.sg/handle/10635/179635
ISSN: 0066-4804
DOI: 10.1128/AAC.02019-15
Rights: Attribution 4.0 International
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