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Title: Deep sequencing in infectious diseases: Immune and pathogen repertoires for the improvement of patient outcomes
Authors: Burkholder, W.F
Newell, E.W
Poidinger, M 
Chen, S 
Fink, K
Keywords: B lymphocyte receptor
T lymphocyte receptor
adaptive immunity
atopic dermatitis
bacterial colonization
deep sequencing
disease transmission
DNA sequence
droplet digital polymerase chain reaction
flow cytometry
gene library
Hepatitis B virus
high throughput sequencing
immunological memory
methicillin resistant Staphylococcus aureus
next generation sequencing
polymerase chain reaction
polymerase chain reaction cloning
RNA sequence
single cell sequencing
treatment outcome
turnaround time
VDJ recombination
Issue Date: 2017
Citation: Burkholder, W.F, Newell, E.W, Poidinger, M, Chen, S, Fink, K (2017). Deep sequencing in infectious diseases: Immune and pathogen repertoires for the improvement of patient outcomes. Frontiers in Immunology 8 (JUN) : 593. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: The inaugural workshop "Deep Sequencing in Infectious Diseases: Immune and Pathogen Repertoires for the Improvement of Patient Outcomes" was held in Singapore on 13-14 October 2016. The aim of the workshop was to discuss the latest trends in using high-throughput sequencing, bioinformatics, and allied technologies to analyze immune and pathogen repertoires and their interplay within the host, bringing together key international players in the field and Singapore-based researchers and clinician-scientists. The focus was in particular on the application of these technologies for the improvement of patient diagnosis, prognosis and treatment, and for other broad public health outcomes. The presentations by scientists and clinicians showed the potential of deep sequencing technology to capture the coevolution of adaptive immunity and pathogens. For clinical applications, some key challenges remain, such as the long turnaround time and relatively high cost of deep sequencing for pathogen identification and characterization and the lack of international standardization in immune repertoire analysis. @ 2017 Burkholder, Newell, Poidinger, Chen and Fink.
Source Title: Frontiers in Immunology
ISSN: 16643224
DOI: 10.3389/fimmu.2017.00593
Rights: Attribution 4.0 International
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