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https://doi.org/10.1038/nature20595
Title: | The seahorse genome and the evolution of its specialized morphology | Authors: | Lin, Q Fan, S Zhang, Y |
Keywords: | astacin calcium binding protein glutamine matrix protein nucleotide phosphoprotein proline fish protein T box transcription factor tbx4 protein, zebrafish zebrafish protein biochemical composition enamel gene expression genome morphology phenotype protein teleost Article conserved sequence evolutionary rate fish gene loss genome Hippocampus comes male molecular evolution molecular genetics morphology nonhuman phylogenomics priority journal sequence analysis teleost zebra fish anatomy and histology animal deficiency evolution fin (organ) gene deletion genetics genome genomics hindlimb metabolism multigene family mutation rate phylogeny physiology reproduction Smegmamorpha time factor Danio rerio Hippocampinae Hippocampus comes Teleostei Animal Fins Animals Biological Evolution Conserved Sequence Fish Proteins Gene Deletion Genome Genomics Hindlimb Male Molecular Sequence Annotation Multigene Family Mutation Rate Phylogeny Reproduction Smegmamorpha T-Box Domain Proteins Time Factors Zebrafish Proteins |
Issue Date: | 2016 | Publisher: | Nature Publishing Group | Citation: | Lin, Q, Fan, S, Zhang, Y (2016). The seahorse genome and the evolution of its specialized morphology. Nature 540 (7633) : 395-399. ScholarBank@NUS Repository. https://doi.org/10.1038/nature20595 | Rights: | Attribution 4.0 International | Abstract: | Seahorses have a specialized morphology that includes a toothless tubular mouth, a body covered with bony plates, a male brood pouch, and the absence of caudal and pelvic fins. Here we report the sequencing and de novo assembly of the genome of the tiger tail seahorse, Hippocampus comes. Comparative genomic analysis identifies higher protein and nucleotide evolutionary rates in H. comes compared with other teleost fish genomes. We identified an astacin metalloprotease gene family that has undergone expansion and is highly expressed in the male brood pouch. We also find that the H. comes genome lacks enamel matrix protein-coding proline/glutamine-rich secretory calcium-binding phosphoprotein genes, which might have led to the loss of mineralized teeth. tbx4, a regulator of hindlimb development, is also not found in H. comes genome. Knockout of tbx4 in zebrafish showed a 'pelvic fin-loss' phenotype similar to that of seahorses. © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. | Source Title: | Nature | URI: | https://scholarbank.nus.edu.sg/handle/10635/179273 | ISSN: | 0028-0836 | DOI: | 10.1038/nature20595 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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