Please use this identifier to cite or link to this item: https://doi.org/10.3945/ajcn.116.151241
Title: Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations
Authors: Midttun, Ø
Theofylaktopoulou, D
McCann, A
Keywords: 25 hydroxyvitamin D
3 hydroxykynurenine
6 n,n' dimethylarginine
alpha tocopherol
arginine
betaine
biological marker
C reactive protein
choline
cotinine
cyanocobalamin
cystathionine
cysteine
dimethylglycine
folic acid
gamma tocopherol
glycine
homoarginine
homocysteine
kynurenine
methionine
n(g),n(g) dimethylarginine
pyridoxal 5 phosphate
retinol
riboflavin
serine
tryptophan
vitamin
vitamin D
xanthurenic acid
alpha tocopherol
biological marker
carbon
kynurenine
retinol
tryptophan
vitamin B complex
vitamin D
adult
aged
Article
Australia
carbon metabolism
cross-sectional study
female
human
male
normal human
race difference
Scandinavia
tryptophan metabolism
United States
vitamin blood level
vitamin deficiency
vitamin metabolism
Asia
blood
dietary supplement
laboratory
middle aged
Aged
alpha-Tocopherol
Asia
Australia
Biomarkers
Carbon
Cross-Sectional Studies
Dietary Supplements
Female
Humans
Kynurenine
Laboratories
Male
Middle Aged
Scandinavian and Nordic Countries
Tryptophan
United States
Vitamin A
Vitamin B Complex
Vitamin D
Issue Date: 2017
Publisher: American Society for Nutrition
Citation: Midttun, Ø, Theofylaktopoulou, D, McCann, A (2017). Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations. American Journal of Clinical Nutrition 105 (6) : 1314-1326. ScholarBank@NUS Repository. https://doi.org/10.3945/ajcn.116.151241
Rights: Attribution 4.0 International
Abstract: Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5?-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26. © 2017 American Society for Nutrition.
Source Title: American Journal of Clinical Nutrition
URI: https://scholarbank.nus.edu.sg/handle/10635/179198
ISSN: 00029165
DOI: 10.3945/ajcn.116.151241
Rights: Attribution 4.0 International
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