Please use this identifier to cite or link to this item: https://doi.org/10.1002/pd.5182
Title: Has noninvasive prenatal testing impacted termination of pregnancy and live birth rates of infants with Down syndrome?
Authors: Hill, M
Barrett, A 
Choolani, M 
Lewis, C
Fisher, J
Chitty, L.S
Keywords: adult
Article
clinical audit
controlled study
Down syndrome
Europe
female
high risk patient
human
infant
live birth
major clinical study
noninvasive prenatal test
pregnancy outcome
pregnancy rate
pregnancy termination
pregnancy test
prenatal screening
priority journal
Singapore
United Kingdom
United States
Down syndrome
induced abortion
maternal serum screening test
pregnancy
statistics and numerical data
Abortion, Induced
Down Syndrome
Female
Humans
Maternal Serum Screening Tests
Pregnancy
Singapore
United Kingdom
Issue Date: 2017
Publisher: John Wiley and Sons Ltd
Citation: Hill, M, Barrett, A, Choolani, M, Lewis, C, Fisher, J, Chitty, L.S (2017). Has noninvasive prenatal testing impacted termination of pregnancy and live birth rates of infants with Down syndrome?. Prenatal Diagnosis 37 (13) : 1281-1290. ScholarBank@NUS Repository. https://doi.org/10.1002/pd.5182
Rights: Attribution 4.0 International
Abstract: Background: Implementation of noninvasive prenatal testing (NIPT) as a highly accurate aneuploidy screening test has raised questions around whether the high uptake may result in more terminations of pregnancies and fewer births of children with Down syndrome (DS). Aim: The aim of the study was to investigate the impact of NIPT on termination and live birth rates for DS. Methods: Literature reporting pregnancy outcomes following NIPT was reviewed. Termination rates were calculated for women with a high-risk NIPT result for DS. Two audits of pregnancy outcomes where NIPT indicated DS were conducted in the United Kingdom and Singapore. Results: Fourteen studies from the United States, Asia, Europe, and the United Kingdom were included in the review. Live births of children with DS were reported in 8 studies. Termination rates following NIPT were unchanged or decreased when compared to termination rates prior to the introduction of NIPT. Audits found 15 of 43 women in the United Kingdom and 2 of 6 in Singapore continued pregnancies following a high-risk NIPT result. Conclusions: Termination rates following the detection of DS by NIPT are unchanged or decreased compared to historical termination rates. Impact on live birth rates may be minimal in settings where termination rates fall. Population-based studies are required to determine the true impact. © 2017 The Authors. Prenatal Diagnosis published by John Wiley & Sons Ltd.
Source Title: Prenatal Diagnosis
URI: https://scholarbank.nus.edu.sg/handle/10635/179071
ISSN: 01973851
DOI: 10.1002/pd.5182
Rights: Attribution 4.0 International
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