Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep29802
Title: Wound healing profiles of hyperopic-small incision lenticule extraction (SMILE)
Authors: Liu, Y.-C 
Ang, H.P
Teo, E.P.W
Lwin, N.C
Yam, G.H.F 
Mehta, J.S 
Keywords: CD11b antigen
fibronectin
heat shock protein 47
animal
confocal microscopy
cornea
diagnostic imaging
eye surgery
hypermetropia
keratometry
keratomileusis
Leporidae
metabolism
optical coherence tomography
pathophysiology
procedures
transmission electron microscopy
ultrastructure
wound healing
Animals
CD11b Antigen
Cornea
Corneal Topography
Fibronectins
HSP47 Heat-Shock Proteins
Hyperopia
Keratomileusis, Laser In Situ
Microscopy, Confocal
Microscopy, Electron, Transmission
Ophthalmologic Surgical Procedures
Rabbits
Tomography, Optical Coherence
Wound Healing
Issue Date: 2016
Citation: Liu, Y.-C, Ang, H.P, Teo, E.P.W, Lwin, N.C, Yam, G.H.F, Mehta, J.S (2016). Wound healing profiles of hyperopic-small incision lenticule extraction (SMILE). Scientific Reports 6 : 29802. ScholarBank@NUS Repository. https://doi.org/10.1038/srep29802
Rights: Attribution 4.0 International
Abstract: Refractive surgical treatment of hyperopia still remains a challenge for refractive surgeons. A new nomogram of small incision lenticule extraction (SMILE) procedure has recently been developed for the treatment of hyperopia. In the present study, we aimed to evaluate the wound healing and inflammatory responses of this new nomogram (hyperopic-SMILE), and compared them to those of hyperopic-laser-assisted in situ keratomileusis (LASIK), using a rabbit model. A total of 26 rabbits were used, and slit lamp biomicroscopy, autorefractor/keratometer, intraocular pressure measurement, anterior segment optical coherence tomography, corneal topography, and in vivo confocal microscopy examinations were performed during the study period of 4 weeks. The corneas were then harvested and subject to immunofluorescence of markers for inflammation (CD11b), wound healing (fibronectin) and keratocyte response (HSP47). The lenticule ultrastructual changes were also analyzed by transmission electron microscopy. Out results showed that hyperopic-SMILE effectively steepened the cornea. Compared to hyperopic-LASIK, hyperopic-SMILE had less postoperative wound healing response and stromal interface reaction, especially in higher refractive correction. However, compared to myopic-SMILE, hyperopic-SMILE resulted in more central deranged collagen fibrils. These results provide more perspective into this new treatment option for hyperopia, and evidence for future laser nomogram modification.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/178891
ISSN: 20452322
DOI: 10.1038/srep29802
Rights: Attribution 4.0 International
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