Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep40569
Title: Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers
Authors: Park, J.E
Sun, Y
Lim, S.K 
Tam, J.P
Dekker, M
Chen, H
Sze, S.K
Keywords: BIM protein
histone
isothiocyanic acid derivative
phenethyl isothiocyanate
phytochemical
polycomb group protein
animal
apoptosis
carcinogenesis
colon tumor
diet
DNA methylation
down regulation
drug effect
gene expression regulation
gene ontology
genetic epigenesis
genetics
metabolism
nude mouse
pathology
phenotype
time factor
tumor cell line
upregulation
Animals
Apoptosis
Bcl-2-Like Protein 11
Carcinogenesis
Cell Line, Tumor
Colonic Neoplasms
Diet
DNA Methylation
Down-Regulation
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Gene Ontology
Histones
Isothiocyanates
Mice, Nude
Phenotype
Phytochemicals
Polycomb-Group Proteins
Time Factors
Up-Regulation
Issue Date: 2017
Citation: Park, J.E, Sun, Y, Lim, S.K, Tam, J.P, Dekker, M, Chen, H, Sze, S.K (2017). Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers. Scientific Reports 7 : 40569. ScholarBank@NUS Repository. https://doi.org/10.1038/srep40569
Rights: Attribution 4.0 International
Abstract: Dietary intake of bioactive phytochemicals including the cruciferous vegetable derivative phenethyl isothiocyanate (PEITC) can reduce risk of human cancers, but possible epigenetic mechanisms of these effects are yet unknown. We therefore sought to identify the molecular basis of PEITC-mediated epigenetic tumor restriction. Colon cancer cells treated with low-dose PEITC for >1 month exhibited stable alterations in expression profile of epigenetic writers/erasers and chromatin-binding of histone deacetylases (HDACs) and Polycomb-group (PcG) proteins. Sustained PEITC exposure not only blocked HDAC binding to euchromatin but was also associated with hypomethylation of PcG target genes that are typically hypermethylated in cancer. Furthermore, PEITC treatment induced expression of pro-Apoptotic genes in tumor cells, which was partially reversed by overexpression of PcG member BMI-1, suggesting opposing roles for PEITC and PcG proteins in control of tumor progression. These data demonstrate that PEITC regulates chromatin binding of key epigenetic writers/erasers and PcG complexes to restrict tumor development. © The Author(s) 2017.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/178710
ISSN: 20452322
DOI: 10.1038/srep40569
Rights: Attribution 4.0 International
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1038_srep40569.pdf2.73 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

16
checked on Nov 20, 2020

Page view(s)

9
checked on Nov 19, 2020

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons