Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-24545-2
Title: Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis
Authors: Wong, C.W
Czarny, B
Metselaar, J.M
Ho, C
Ng, S.R
Barathi, A.V 
Storm, G
Wong, T.T
Keywords: antiinflammatory agent
liposome
steroid
animal
cataract
complication
conjunctiva
disease model
drug effect
intraocular pressure
Leporidae
pathology
severity of illness index
uveitis
Animals
Anti-Inflammatory Agents
Cataract
Conjunctiva
Disease Models, Animal
Intraocular Pressure
Liposomes
Rabbits
Severity of Illness Index
Steroids
Uveitis
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Wong, C.W, Czarny, B, Metselaar, J.M, Ho, C, Ng, S.R, Barathi, A.V, Storm, G, Wong, T.T (2018). Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis. Scientific Reports 8 (1) : 6604. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-24545-2
Rights: Attribution 4.0 International
Abstract: Non-infectious anterior uveitis (AU) is a potentially sight threatening inflammatory condition. The current gold standard for treatment is topical steroids, but low ocular bioavailability and compliance issues with the intensive dosing regimen limit the efficacy of this treatment. Liposomes as a drug delivery system may help to overcome these problems. We studied the efficacy of a PEG-liposomal formulation of liposomal steroids, administered as a single subconjunctival dose, in the treatment of experimental uveitis in rabbit eyes. Rabbits that received subconjunctival liposomal triamcinolone acetonide phosphate (LTAP) or liposomal prednisolone phosphate (LPP) had significantly lower mean inflammatory scores than untreated controls on Day 4 after induction of uveitis (LPP vs controls, p = 0.049) and 8 (LPP vs controls, p = 0.007; LTAP vs controls, p = 0.019), and lower scores than rabbits given topical PredForte1% 4 times a day on Day 8 (p = 0.03). After antigen rechallenge, the subconjunctival liposomal steroid groups continued to have greater suppression of inflammation than untreated controls on Day 11 (p = 0.02). Localization of liposomes in inflamed ocular tissue was confirmed by histology and immunostaining, and persisted in the eye for at least one month. Our study demonstrates that a single subconjunctival injection of liposomal steroids induces effective and sustained anti-inflammatory action. © 2018 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/178416
ISSN: 2045-2322
DOI: 10.1038/s41598-018-24545-2
Rights: Attribution 4.0 International
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