Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-01719-y
Title: Features of glycemic variations in drug naïve type 2 diabetic patients with different HbA1c values
Authors: Li, F.-F
Liu, B.-L
Yan, R.-N
Zhu, H.-H
Zhou, P.-H
Li, H.-Q
Su, X.-F
Wu, J.-D
Zhang, D.-F
Ye, L 
Ma, J.-H
Keywords: glycosylated hemoglobin
blood
blood glucose monitoring
female
glucose blood level
glucose tolerance test
human
male
metabolism
middle aged
non insulin dependent diabetes mellitus
Blood Glucose
Blood Glucose Self-Monitoring
Diabetes Mellitus, Type 2
Female
Glucose Tolerance Test
Glycated Hemoglobin A
Humans
Male
Middle Aged
Issue Date: 2017
Citation: Li, F.-F, Liu, B.-L, Yan, R.-N, Zhu, H.-H, Zhou, P.-H, Li, H.-Q, Su, X.-F, Wu, J.-D, Zhang, D.-F, Ye, L, Ma, J.-H (2017). Features of glycemic variations in drug naïve type 2 diabetic patients with different HbA1c values. Scientific Reports 7 (1) : 1583. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-01719-y
Rights: Attribution 4.0 International
Abstract: To define the features of glycemic variations in drug naïve type 2 diabetic (T2D) patients with different HbA1c values using continuous glucose monitoring (CGM), a total of 195 drug naïve T2D patients were admitted. The subjects were divided into the following groups: lower HbA1c values (?8%), moderate HbA1c values (>8% and ?10%), and higher HbA1c values (>10%). The patients underwent oral glucose tolerance tests and were then subjected to 3-day CGM. The primary endpoint was the differences in the 24-hr mean amplitude of glycemic excursions (MAGE) in patients with different HbA1c values. Patients with higher HbA1c values had larger MAGEs than those in the moderate and lower groups (7.44 ± 3.00 vs. 6.30 ± 2.38, P < 0.05, 7.44 ± 3.00 vs. 5.20 ± 2.35, P < 0.01, respectively). The 24-hr mean glucose concentrations increased incrementally in the patients with lower, moderate and higher HbA1c values. Moreover, the patients with higher HbA1c values exhibited higher peak glucose concentrations and prolongation in the time to peak glucose. Patients with higher HbA1c values had larger MAGE compared with those with lower and moderate HbA1c values. Our data indicated patients with higher HbA1c values should receive special therapy aimed at reducing the larger glycemic variations. © 2017 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/178323
ISSN: 20452322
DOI: 10.1038/s41598-017-01719-y
Rights: Attribution 4.0 International
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