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Title: Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: A preliminary study
Authors: Hong, X
Lu, Z.K
Teh, I
Nasrallah, F.A
Teo, W.P
Ang, K.K
Phua, K.S
Guan, C 
Chew, E 
Chuang, K.-H
Keywords: adult
brain computer interface
cerebrovascular accident
chronic disease
controlled study
guided imagery
middle aged
nerve cell plasticity
nuclear magnetic resonance imaging
randomized controlled trial
stroke rehabilitation
transcranial direct current stimulation
Brain-Computer Interfaces
Chronic Disease
Imagery (Psychotherapy)
Magnetic Resonance Imaging
Middle Aged
Neuronal Plasticity
Stroke Rehabilitation
Transcranial Direct Current Stimulation
Issue Date: 2017
Citation: Hong, X, Lu, Z.K, Teh, I, Nasrallah, F.A, Teo, W.P, Ang, K.K, Phua, K.S, Guan, C, Chew, E, Chuang, K.-H (2017). Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: A preliminary study. Scientific Reports 7 (1) : 9222. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Brain-computer interface-assisted motor imagery (MI-BCI) or transcranial direct current stimulation (tDCS) has been used in stroke rehabilitation, though their combinatory effect is unknown. We investigated brain plasticity following a combined MI-BCI and tDCS intervention in chronic subcortical stroke patients with unilateral upper limb disability. Nineteen patients were randomized into tDCS and sham-tDCS groups. Diffusion and perfusion MRI, and transcranial magnetic stimulation were used to study structural connectivity, cerebral blood flow (CBF), and corticospinal excitability, respectively, before and 4 weeks after the 2-week intervention. After quality control, thirteen subjects were included in the CBF analysis. Eleven healthy controls underwent 2 sessions of MRI for reproducibility study. Whereas motor performance showed comparable improvement, long-lasting neuroplasticity can only be detected in the tDCS group, where white matter integrity in the ipsilesional corticospinal tract and bilateral corpus callosum was increased but sensorimotor CBF was decreased, particularly in the ipsilesional side. CBF change in the bilateral parietal cortices also correlated with motor function improvement, consistent with the increased white matter integrity in the corpus callosum connecting these regions, suggesting an involvement of interhemispheric interaction. The preliminary results indicate that tDCS may facilitate neuroplasticity and suggest the potential for refining rehabilitation strategies for stroke patients. © 2017 The Author(s).
Source Title: Scientific Reports
ISSN: 20452322
DOI: 10.1038/s41598-017-08928-5
Rights: Attribution 4.0 International
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