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https://doi.org/10.1038/s41598-017-08928-5
Title: | Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: A preliminary study |
Authors: | Hong, X Lu, Z.K Teh, I Nasrallah, F.A Teo, W.P Ang, K.K Phua, K.S Guan, C Chew, E Chuang, K.-H |
Keywords: | adult aged brain computer interface cerebrovascular accident chronic disease controlled study female guided imagery human male middle aged nerve cell plasticity nuclear magnetic resonance imaging pathophysiology procedures randomized controlled trial stroke rehabilitation transcranial direct current stimulation Adult Aged Brain-Computer Interfaces Chronic Disease Female Humans Imagery (Psychotherapy) Magnetic Resonance Imaging Male Middle Aged Neuronal Plasticity Stroke Stroke Rehabilitation Transcranial Direct Current Stimulation |
Issue Date: | 2017 |
Citation: | Hong, X, Lu, Z.K, Teh, I, Nasrallah, F.A, Teo, W.P, Ang, K.K, Phua, K.S, Guan, C, Chew, E, Chuang, K.-H (2017). Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: A preliminary study. Scientific Reports 7 (1) : 9222. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-08928-5 |
Rights: | Attribution 4.0 International |
Abstract: | Brain-computer interface-assisted motor imagery (MI-BCI) or transcranial direct current stimulation (tDCS) has been used in stroke rehabilitation, though their combinatory effect is unknown. We investigated brain plasticity following a combined MI-BCI and tDCS intervention in chronic subcortical stroke patients with unilateral upper limb disability. Nineteen patients were randomized into tDCS and sham-tDCS groups. Diffusion and perfusion MRI, and transcranial magnetic stimulation were used to study structural connectivity, cerebral blood flow (CBF), and corticospinal excitability, respectively, before and 4 weeks after the 2-week intervention. After quality control, thirteen subjects were included in the CBF analysis. Eleven healthy controls underwent 2 sessions of MRI for reproducibility study. Whereas motor performance showed comparable improvement, long-lasting neuroplasticity can only be detected in the tDCS group, where white matter integrity in the ipsilesional corticospinal tract and bilateral corpus callosum was increased but sensorimotor CBF was decreased, particularly in the ipsilesional side. CBF change in the bilateral parietal cortices also correlated with motor function improvement, consistent with the increased white matter integrity in the corpus callosum connecting these regions, suggesting an involvement of interhemispheric interaction. The preliminary results indicate that tDCS may facilitate neuroplasticity and suggest the potential for refining rehabilitation strategies for stroke patients. © 2017 The Author(s). |
Source Title: | Scientific Reports |
URI: | https://scholarbank.nus.edu.sg/handle/10635/178305 |
ISSN: | 20452322 |
DOI: | 10.1038/s41598-017-08928-5 |
Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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