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https://doi.org/10.3390/nu10030291
Title: | Iodine status during pregnancy in a region of mild-to-moderate iodine deficiency is not associated with adverse obstetric outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC) | Authors: | Torlinska, B Bath, S.C Janjua, A Boelaert, K Chan, S.-Y |
Keywords: | creatinine iodine iodine adult anemia Article breech extraction cesarean section cohort analysis controlled study disease severity female glucosuria human hyperglycemia iodine deficiency large for gestational age major clinical study maternal hypertension postpartum hemorrhage preeclampsia pregnancy diabetes mellitus pregnancy outcome premature labor pulmonary hypertension small for date infant spontaneous abortion vaginal delivery child death deficiency infant longitudinal study maternal nutrition newborn pregnancy pregnancy complication urine Abortion, Spontaneous Adult Female Humans Infant Infant Death Infant, Newborn Iodine Longitudinal Studies Pregnancy Pregnancy Complications Pregnancy Outcome Prenatal Nutritional Physiological Phenomena |
Issue Date: | 2018 | Citation: | Torlinska, B, Bath, S.C, Janjua, A, Boelaert, K, Chan, S.-Y (2018). Iodine status during pregnancy in a region of mild-to-moderate iodine deficiency is not associated with adverse obstetric outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC). Nutrients 10 (3) : 291. ScholarBank@NUS Repository. https://doi.org/10.3390/nu10030291 | Rights: | Attribution 4.0 International | Abstract: | Severe iodine deficiency during pregnancy has been associated with pregnancy/neonatal loss, and adverse pregnancy outcomes; however, the impact of mild-to-moderate iodine insufficiency, though prevalent in pregnancy, is not well-documented. We assessed whether mild iodine deficiency during pregnancy was associated with pregnancy/infant loss, or with other adverse pregnancy outcomes. We used samples and data from the Avon Longitudinal Study of Parents and Children (ALSPAC), from 3140 singleton pregnancies and from a further 42 women with pregnancy/infant loss. The group was classified as mildly-to-moderately iodine deficient with a median urinary iodine concentration of 95.3 µg/L (IQR 57.0-153.0; median urinary iodine-to-creatinine ratio (UI/Creat) 124 ug/g, IQR 82-198). The likelihood of pregnancy/infant loss was not different across four UI/Creat groups (<50,50-149,150-250, >250 µg/g). The incidence of pre-eclampsia, non-proteinuric gestational hypertension, gestational diabetes, glycosuria, anaemia, post-partum haemorrhage, preterm delivery, mode of delivery, being small for gestational age, and large for gestational age did not differ significantly among UI/Creat groups, nor were there any significant differences in the median UI/Creat. We conclude that maternal iodine status was not associated with adverse pregnancy outcomes in a mildly-to-moderately iodine-deficient pregnant population. However, in view of the low number of women with pregnancy/infant loss in our study, further research is required. © 2018 by the authors. Licensee MDPI, Basel, Switzerland. | Source Title: | Nutrients | URI: | https://scholarbank.nus.edu.sg/handle/10635/178257 | ISSN: | 20726643 | DOI: | 10.3390/nu10030291 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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