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https://doi.org/10.1186/s13073-017-0491-4
Title: | A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder | Authors: | Polimanti, R Amstadter, A.B Stein, M.B |
Keywords: | adult age Article body build body mass cohort analysis controlled study disease association European American female female body shape genetic association genome-wide association study human major clinical study pleiotropy posttraumatic stress disorder priority journal reproductive behavior risk factor sexual intercourse waist circumference women's health genetic predisposition genetics male middle aged morphometry posttraumatic stress disorder reproduction risk sexual behavior single nucleotide polymorphism Body Weights and Measures Female Genetic Predisposition to Disease Humans Male Middle Aged Polymorphism, Single Nucleotide Reproduction Risk Sexual Behavior Stress Disorders, Post-Traumatic |
Issue Date: | 2017 | Citation: | Polimanti, R, Amstadter, A.B, Stein, M.B (2017). A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder. Genome Medicine 9 (1) : 99. ScholarBank@NUS Repository. https://doi.org/10.1186/s13073-017-0491-4 | Rights: | Attribution 4.0 International | Abstract: | Background: The nature and underlying mechanisms of the observed increased vulnerability to posttraumatic stress disorder (PTSD) in women are unclear. Methods: We investigated the genetic overlap of PTSD with anthropometric traits and reproductive behaviors and functions in women. The analysis was conducted using female-specific summary statistics from large genome-wide association studies (GWAS) and a cohort of 3577 European American women (966 PTSD cases and 2611 trauma-exposed controls). We applied a high-resolution polygenic score approach and Mendelian randomization analysis to investigate genetic correlations and causal relationships. Results: We observed an inverse association of PTSD with genetically determined anthropometric traits related to body shape, independent of body mass index (BMI). The top association was related to BMI-adjusted waist circumference (WCadj; R = -0.079, P < 0.001, Q = 0.011). We estimated a relative decrease of 64.6% (95% confidence interval = 27.5-82.7) in the risk of PTSD per 1-SD increase in WCadj. MR-Egger regression intercept analysis showed no evidence of pleiotropic effects in this association (Ppleiotropy = 0.979). We also observed associations of genetically determined WCadj with age at first sexual intercourse and number of sexual partners (P = 0.013 and P < 0.001, respectively). Conclusions: There is a putative causal relationship between genetically determined female body shape and PTSD, which could be mediated by evolutionary mechanisms involved in human sexual behaviors. © 2017 The Author(s). | Source Title: | Genome Medicine | URI: | https://scholarbank.nus.edu.sg/handle/10635/178132 | ISSN: | 1756994X | DOI: | 10.1186/s13073-017-0491-4 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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