Please use this identifier to cite or link to this item: https://doi.org/10.1186/1471-2334-9-46
Title: Risk and prognostic significance of tuberculosis in patients from The TREAT Asia HIV Observational Database
Authors: Zhou, J
Elliott, J
Li, P.C.K
Lim, P.L 
Kiertiburanakul, S
Kumarasamy, N
Merati, T.P
Pujari, S
Chen, Y.-M.A
Phanuphak, P
Vonthanak, S
Sirisanthana, T
Sungkanuparph, S
Lee, C.K.C
Kamarulzaman, A
Oka, S
Zhang, F
Tau, G
Ditangco, R
Keywords: antiretrovirus agent
RNA directed DNA polymerase inhibitor
anti human immunodeficiency virus agent
adult
age
article
CD4 lymphocyte count
extrapulmonary tuberculosis
female
heterosexuality
highly active antiretroviral therapy
homosexuality
human
Human immunodeficiency virus infected patient
Human immunodeficiency virus infection
infection risk
lung tuberculosis
major clinical study
male
mortality
overall survival
prevalence
prognosis
risk assessment
risk factor
sexual intercourse
treatment duration
tuberculosis
virus load
Asia
factual database
Human immunodeficiency virus infection
incidence
proportional hazards model
statistics
tuberculosis
Adult
Anti-HIV Agents
Asia
Databases, Factual
Female
HIV Infections
Humans
Incidence
Male
Prognosis
Proportional Hazards Models
Risk Factors
Tuberculosis
Issue Date: 2009
Citation: Zhou, J, Elliott, J, Li, P.C.K, Lim, P.L, Kiertiburanakul, S, Kumarasamy, N, Merati, T.P, Pujari, S, Chen, Y.-M.A, Phanuphak, P, Vonthanak, S, Sirisanthana, T, Sungkanuparph, S, Lee, C.K.C, Kamarulzaman, A, Oka, S, Zhang, F, Tau, G, Ditangco, R (2009). Risk and prognostic significance of tuberculosis in patients from The TREAT Asia HIV Observational Database. BMC Infectious Diseases 9 : 46. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2334-9-46
Rights: Attribution 4.0 International
Abstract: Background: To assess the risk and the prognostic significance of tuberculosis (TB) diagnosis in patients from The TREAT Asia HIV Observational Database, a multi-centre prospective cohort of HIV-infected patients receiving HIV care in the Asia-Pacific region. Methods: The risk of TB diagnosis after recruitment was assessed in patients with prospective follow-up. TB diagnosis was fitted as a time-dependent variable in assessing overall survival. Results: At baseline, 22% of patients were diagnosed with TB. TB incidence was 1.98 per 100 person-years during follow up, with predictors including younger age, lower recent CD4 count, duration of antiretroviral treatment, and living in high TB burden countries. Among 3279 patients during 6968 person-years, 142 died (2.04 per 100 person-years). Compared to patients with CDC category A or B illness only, mortality was marginally higher in patients with single Non-TB AIDS defining illness (ADI), or TB only (adjusted HR 1.35, p = 0.173) and highest in patients with multiple non-TB AIDS or both TB and other ADI (adjusted HR 2.21, p < 0.001). Conclusion: The risk of TB diagnosis was associated with increasing immunodeficiency and partly reduced by antiretroviral treatment. The prognosis of developing TB appeared to be similar to that following a diagnosis of other non-TB ADI. © 2009 Zhou et al; licensee BioMed Central Ltd.
Source Title: BMC Infectious Diseases
URI: https://scholarbank.nus.edu.sg/handle/10635/177955
ISSN: 14712334
DOI: 10.1186/1471-2334-9-46
Rights: Attribution 4.0 International
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