Please use this identifier to cite or link to this item: https://doi.org/10.1177/1479164115621667
Title: A randomised controlled trial evaluating the impact of targeted Vitamin D supplementation on endothelial function in type 2 diabetes mellitus: The DIMENSION trial
Authors: Dalan R. 
Liew H.
Assam P.N. 
Chan E.S.Y.
Siddiqui F.J. 
Tan A.W.K.
Chew D.E.K.
Boehm B.O.
Leow M.K.S. 
Keywords: cholecalciferol
endothelial function
type 2 diabetes
Vitamin D
Issue Date: 2016
Publisher: SAGE Publications Ltd
Citation: Dalan R., Liew H., Assam P.N., Chan E.S.Y., Siddiqui F.J., Tan A.W.K., Chew D.E.K., Boehm B.O., Leow M.K.S. (2016). A randomised controlled trial evaluating the impact of targeted Vitamin D supplementation on endothelial function in type 2 diabetes mellitus: The DIMENSION trial. Diabetes and Vascular Disease Research 13 (3) : 192 - 200. ScholarBank@NUS Repository. https://doi.org/10.1177/1479164115621667
Abstract: We sought to determine if vitamin D supplementation, to target 25(OH)D concentrations of 30-40 ng/mL, improves endothelial function in Singapore's multi-ethnic type 2 diabetes mellitus population. We randomised 64 type 2 diabetes mellitus patients with hypovitaminosis D to cholecalciferol 4000 International Unit/matching placebo [baseline 25(OH)D < 20 ng/mL] or cholecalciferol 2000 International Unit/matching placebo [baseline 25(OH)D: 20-30 ng/mL] daily for 16 weeks with a down titration at 8 weeks if 25(OH)D > 30 ng/mL. Endothelial function was assessed by peripheral tonometry (reactive hyperaemia index-endothelial peripheral arterial tonometry) and vascular biomarkers: E-selectin, von-Willebrand factor and high-sensitivity C-reactive protein. We compared the change from baseline parameters in the two groups using Student's t-test or Kruskal-Wallis test. A log-normal multivariate regression analysis was used to adjust for relevant baseline variables. The median reactive hyperaemia index in the vitamin D group increased from 0.65 (interquartile range: 0.42) to 0.73 (interquartile range: 0.36), whereas it decreased from 0.73 (interquartile range: 0.65) to 0.65 (interquartile range: 0.38) (p = 0.02) in the placebo group. After adjustment for baseline variables, the change was not statistically significant for reactive hyperaemia index (p = 0.07) and for other vascular biomarkers (p > 0.05). Targeted vitamin D supplementation for 16 weeks resulted in a small but non-significant improvement in endothelial function in a type 2 diabetes mellitus cohort. © The Author(s) 2016.
Source Title: Diabetes and Vascular Disease Research
URI: https://scholarbank.nus.edu.sg/handle/10635/177511
ISSN: 1479-1641
DOI: 10.1177/1479164115621667
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