Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mbs.2014.01.001
Title: A novel minimal mathematical model of the hypothalamus-pituitary-thyroid axis validated for individualized clinical applications
Authors: Goede S.L.
Leow M.K.S. 
Smit J.W.A.
Dietrich J.W.
Keywords: Clinical validation
Individualized therapeutic target
Logarithmic-linear relationship
Negative exponential
Parameterization
Issue Date: 2014
Citation: Goede S.L., Leow M.K.S., Smit J.W.A., Dietrich J.W. (2014). A novel minimal mathematical model of the hypothalamus-pituitary-thyroid axis validated for individualized clinical applications. Mathematical Biosciences 249 (1) : 1-7. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mbs.2014.01.001
Abstract: The hypothalamus-pituitary-thyroid (HPT) axis represents a complex, non-linear thyroid hormone system in vertebrates governed by numerous variables. The common modeling approach until now aims at a comprehensive inclusion of all known physiological influences. In contrast, we develop a parsimonious mathematical model that integrates the hypothalamus-pituitary (HP) complex as an endocrinologic unit based on a parameterized negative exponential function between free thyroxine (FT4) as stimulus and thyrotropin (thyroid stimulating hormone, TSH) as response. Model validation with clinical data obtained from geographically different hospitals revealed a goodness-of-fit largely ranging between 90%
Source Title: Mathematical Biosciences
URI: https://scholarbank.nus.edu.sg/handle/10635/177447
ISSN: 00255564
DOI: 10.1016/j.mbs.2014.01.001
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