Please use this identifier to cite or link to this item: https://doi.org/10.3389/fonc.2018.00395
Title: Diagnosis and Management of Radiation Necrosis in Patients With Brain Metastases
Authors: Vellayappan, Balamurugan 
Tan, Char Loo 
Yong, Clement 
Khor, Lih Kin
Koh, Wee Yao 
Yeo, Tseng Tsai
Detsky, Jay
Lo, Simon
Sahgal, Arjun
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
Brain metastases (BM)
Stereotactic radiosurgery
Whole brain radiation therapy
Radiation necrosis
MRI imaging techniques
POSITRON-EMISSION-TOMOGRAPHY
HYPERBARIC-OXYGEN THERAPY
GAMMA-KNIFE RADIOSURGERY
FRACTIONATED STEREOTACTIC RADIOSURGERY
RANDOMIZED-TRIAL
RECURRENT TUMOR
INTRACRANIAL TUMORS
BARRIER DISRUPTION
GLIOMA RECURRENCE
IRRADIATED VOLUME
Issue Date: 28-Sep-2018
Publisher: FRONTIERS MEDIA SA
Citation: Vellayappan, Balamurugan, Tan, Char Loo, Yong, Clement, Khor, Lih Kin, Koh, Wee Yao, Yeo, Tseng Tsai, Detsky, Jay, Lo, Simon, Sahgal, Arjun (2018-09-28). Diagnosis and Management of Radiation Necrosis in Patients With Brain Metastases. FRONTIERS IN ONCOLOGY 8. ScholarBank@NUS Repository. https://doi.org/10.3389/fonc.2018.00395
Abstract: The use of radiotherapy, either in the form of stereotactic radiosurgery (SRS) or whole-brain radiotherapy (WBRT), remains the cornerstone for the treatment of brain metastases (BM). As the survival of patients with BM is being prolonged, due to improved systemic therapy (i.e., for better extra-cranial control) and increased use of SRS (i.e., for improved intra-cranial control), patients are clinically manifesting late effects of radiotherapy. One of these late effects is radiation necrosis (RN). Unfortunately, symptomatic RN is notoriously hard to diagnose and manage. The features of RN overlap considerably with tumor recurrence, and misdiagnosing RN as tumor recurrence may lead to deleterious treatment which may cause detrimental effects to the patient. In this review, we will explore the pathophysiology of RN, risk factors for its development, and the strategies to evaluate and manage RN.
Source Title: FRONTIERS IN ONCOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/177349
ISSN: 2234943X
DOI: 10.3389/fonc.2018.00395
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