Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms14012072
Title: Blood microRNAs in low or no risk ischemic stroke patients
Authors: Tan, J.R 
Tan, K.S
Koo, Y.X
Yong, F.L
Wang, C.W
Armugam, A 
Jeyaseelan, K 
Keywords: microRNA
microRNA
adult
article
brain ischemia
controlled study
dyslipidemia
functional status
gene expression
human
hypertension
non insulin dependent diabetes mellitus
Rankin scale
adolescent
blood
brain ischemia
clinical trial
female
male
middle aged
risk factor
Stroke
Adolescent
Adult
Brain Ischemia
Female
Humans
Male
MicroRNAs
Middle Aged
Risk Factors
Stroke
Issue Date: 2013
Citation: Tan, J.R, Tan, K.S, Koo, Y.X, Yong, F.L, Wang, C.W, Armugam, A, Jeyaseelan, K (2013). Blood microRNAs in low or no risk ischemic stroke patients. International Journal of Molecular Sciences 14 (1) : 2072-2084. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms14012072
Abstract: Ischemic stroke is a multi-factorial disease where some patients present themselves with little or no risk factors. Blood microRNA expression profiles are becoming useful in the diagnosis and prognosis of human diseases. We therefore investigated the blood microRNA profiles in young stroke patients who presented with minimal or absence of risk factors for stroke such as type 2 diabetes, dyslipidemia and hypertension. Blood microRNA profiles from these patients varied with stroke subtypes as well as different functional outcomes (based on modified Rankin Score). These microRNAs have been shown to target genes that are involved in stroke pathogenesis. The findings from our study suggest that molecular mechanisms in stroke pathogenesis involving low or no risk ischemic stroke patients could differ substantially from those with pre-existing risk factors. © 2013 by the authors; licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Molecular Sciences
URI: https://scholarbank.nus.edu.sg/handle/10635/176183
ISSN: 1661-6596
DOI: 10.3390/ijms14012072
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