Please use this identifier to cite or link to this item: https://doi.org/10.1186/s40880-016-0168-1
Title: The most important questions in cancer research and clinical oncology : Question 1. Could the vertical transmission of human papilloma virus (HPV) infection account for the cause, characteristics, and epidemiology of HPV-positive oropharyngeal carcinoma, non-smoking East Asian female lung adenocarcinoma, and/or East Asian triple-negative breast carcinoma?
Authors: Wee, J.T 
Poh, S.S
Keywords: adenocarcinoma
animal
disease model
Far East
female
human
Lung Neoplasms
mouse
Oropharyngeal Neoplasms
papillomavirus infection
transmission
Triple Negative Breast Neoplasms
vertical transmission
virology
Adenocarcinoma
Animals
Disease Models, Animal
Far East
Female
Humans
Infectious Disease Transmission, Vertical
Lung Neoplasms
Mice
Oropharyngeal Neoplasms
Papillomavirus Infections
Triple Negative Breast Neoplasms
Issue Date: 2017
Citation: Wee, J.T, Poh, S.S (2017). The most important questions in cancer research and clinical oncology : Question 1. Could the vertical transmission of human papilloma virus (HPV) infection account for the cause, characteristics, and epidemiology of HPV-positive oropharyngeal carcinoma, non-smoking East Asian female lung adenocarcinoma, and/or East Asian triple-negative breast carcinoma?. Chinese journal of cancer 36 (1) : 13. ScholarBank@NUS Repository. https://doi.org/10.1186/s40880-016-0168-1
Abstract: Specific research foci: (1) Mouse models of gamma-herpes virus-68 (γHV-68) and polyomavirus (PyV) infections during neonatal versus adult life. (2) For human papilloma virus (HPV)-positive oropharyngeal carcinoma (OPC)-(a) Asking the question: Is oral sex a powerful carcinogen? (b) Examining the evidence for the vertical transmission of HPV infection. (c) Examining the relationship between HPV and Epstein-Barr virus (EBV) infections and nasopharyngeal cancer (NPC) in West European, East European, and East Asian countries. (d) Examining the association between HPV-positive OPC and human leukocyte antigen (HLA). (3) For non-smoking East Asian female lung adenocarcinoma-(a) Examining the incidence trends of HPV-positive OPC and female lung adenocarcinoma according to birth cohorts. (b) Examining the association between female lung adenocarcinoma and HPV. (c) Examining the associations of lung adenocarcinoma with immune modulating factors. (4) For triple-negative breast carcinoma (TNBC) in East Asians-(a) Examining the association between TNBC and HPV. (b) Examining the unique epidemiological characteristics of patients with TNBC. A summary "epidemiological" model tying some of these findings together.
Source Title: Chinese journal of cancer
URI: https://scholarbank.nus.edu.sg/handle/10635/176101
ISSN: 1944-446X
DOI: 10.1186/s40880-016-0168-1
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