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Title: Leukemia-initiating cells in T-cell acute lymphoblastic leukemia
Authors: Tan, S.H 
Bertulfo, F.C 
Sanda, T 
Keywords: CD34 antigen
chemokine receptor CXCR4
icn1 protein
Notch1 receptor
octamer transcription factor 4
protein Myb
stromal cell derived factor 1
transcription factor GATA 3
transcription factor LMO2
transcription factor NANOG
transcription factor RUNX1
transcription factor Sox2
transcription factor TAL1
unclassified drug
acute lymphoblastic leukemia
acute myeloid leukemia
cancer stem cell
cell differentiation
DNA transcription
down regulation
gene expression
hematopoietic stem cell
intracellular signaling
leukemia initiating cell
molecular pathology
tumor microenvironment
Issue Date: 2017
Citation: Tan, S.H, Bertulfo, F.C, Sanda, T (2017). Leukemia-initiating cells in T-cell acute lymphoblastic leukemia. Frontiers in Oncology 7 (SEP) : 218. ScholarBank@NUS Repository.
Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy characterized by the clonal proliferation of immature T-cell precursors. T-ALL has many similar pathophysiological features to acute myeloid leukemia, which has been extensively studied in the establishment of the cancer stem cell (CSC) theory, but the CSC concept in T-ALL is still debatable. Although leukemia-initiating cells (LICs), which can generate leukemia in a xenograft setting, have been found in both human T-ALL patients and animal models, the nature and origin of LICs are largely unknown. In this review, we discuss recent studies on LICs in T-ALL and the potential mechanisms of LIC emergence in this disease. We focus on the oncogenic transcription factors TAL1, LMO2, and NOTCH1 and highlight the significance of the transcriptional regulatory programs in normal hematopoietic stem cells and T-ALL. © 2017 Tan, Bertulfo and Sanda.
Source Title: Frontiers in Oncology
ISSN: 2234-943X
DOI: 10.3389/fonc.2017.00218
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