Please use this identifier to cite or link to this item: https://doi.org/10.3389/fonc.2017.00218
Title: Leukemia-initiating cells in T-cell acute lymphoblastic leukemia
Authors: Tan, S.H 
Bertulfo, F.C 
Sanda, T 
Keywords: CD34 antigen
chemokine receptor CXCR4
icn1 protein
Notch1 receptor
octamer transcription factor 4
protein Myb
stromal cell derived factor 1
transcription factor GATA 3
transcription factor LMO2
transcription factor NANOG
transcription factor RUNX1
transcription factor Sox2
transcription factor TAL1
unclassified drug
acute lymphoblastic leukemia
acute myeloid leukemia
cancer stem cell
carcinogenesis
cell differentiation
DNA transcription
down regulation
epigenetics
gene expression
hematopoietic stem cell
human
intracellular signaling
leukemia initiating cell
molecular pathology
mutation
nonhuman
Review
thymocyte
tumor microenvironment
Issue Date: 2017
Citation: Tan, S.H, Bertulfo, F.C, Sanda, T (2017). Leukemia-initiating cells in T-cell acute lymphoblastic leukemia. Frontiers in Oncology 7 (SEP) : 218. ScholarBank@NUS Repository. https://doi.org/10.3389/fonc.2017.00218
Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy characterized by the clonal proliferation of immature T-cell precursors. T-ALL has many similar pathophysiological features to acute myeloid leukemia, which has been extensively studied in the establishment of the cancer stem cell (CSC) theory, but the CSC concept in T-ALL is still debatable. Although leukemia-initiating cells (LICs), which can generate leukemia in a xenograft setting, have been found in both human T-ALL patients and animal models, the nature and origin of LICs are largely unknown. In this review, we discuss recent studies on LICs in T-ALL and the potential mechanisms of LIC emergence in this disease. We focus on the oncogenic transcription factors TAL1, LMO2, and NOTCH1 and highlight the significance of the transcriptional regulatory programs in normal hematopoietic stem cells and T-ALL. © 2017 Tan, Bertulfo and Sanda.
Source Title: Frontiers in Oncology
URI: https://scholarbank.nus.edu.sg/handle/10635/176079
ISSN: 2234-943X
DOI: 10.3389/fonc.2017.00218
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_3389_fonc_2017_00218.pdf2.71 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

21
checked on Sep 29, 2022

Page view(s)

155
checked on Sep 22, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.