Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep08669
Title: Ultrasmall glutathione-protected gold nanoclusters as next generation radiotherapy sensitizers with high tumor uptake and high renal clearance
Authors: Zhang, X.-D
Luo, Z
Chen, J
Song, S
Yuan, X
Shen, X
Wang, H
Sun, Y
Gao, K
Zhang, L
Fan, S
Leong, D.T 
Guo, M
Xie, J 
Keywords: glutathione
gold
metal nanoparticle
radiosensitizing agent
animal
antibody specificity
Bagg albino mouse
blood
computer assisted tomography
drug effects
hydrodynamics
kidney
male
metabolism
neoplasm
pathology
radiography
scintiscanning
three dimensional imaging
time
tumor volume
ultrastructure
ultraviolet spectrophotometry
Animals
Glutathione
Gold
Hydrodynamics
Imaging, Three-Dimensional
Kidney
Male
Metal Nanoparticles
Mice, Inbred BALB C
Neoplasms
Organ Specificity
Radiation-Sensitizing Agents
Spectrophotometry, Ultraviolet
Time Factors
Tomography, X-Ray Computed
Tumor Burden
Issue Date: 2015
Publisher: Nature Publishing Group
Citation: Zhang, X.-D, Luo, Z, Chen, J, Song, S, Yuan, X, Shen, X, Wang, H, Sun, Y, Gao, K, Zhang, L, Fan, S, Leong, D.T, Guo, M, Xie, J (2015). Ultrasmall glutathione-protected gold nanoclusters as next generation radiotherapy sensitizers with high tumor uptake and high renal clearance. Scientific Reports 5 : 8669. ScholarBank@NUS Repository. https://doi.org/10.1038/srep08669
Abstract: Radiotherapy is often the most straightforward first line cancer treatment for solid tumors. While it is highly effective against tumors, there is also collateral damage to healthy proximal tissues especially with high doses. The use of radiosensitizers is an effective way to boost the killing efficacy of radiotherapy against the tumor while drastically limiting the received dose and reducing the possible damage to normal tissues. Here, we report the design and application of a good radiosensitizer by using ultrasmall Au29-43(SG)27-37 nanoclusters (<2 nm) with a naturally-occurring peptide (e.g., glutathione or GSH) as the protecting shell. The GSH-coated Au29-43(SG)27-37 nanoclusters can escape the RES absorption, leading to a good tumor uptake (?8.1% ID/g at 24 h post injection). As a result, the as-designed Au nanoclusters led to a strong enhancement for radiotherapy, as well as a negligible damage to normal tissues. After the treatment, the ultrasmall Au29-43(SG)27-37 nanoclusters can be efficiently cleared by the kidney, thereby avoiding potential long-term side-effects caused by the accumulation of gold atoms in the body. Our data suggest that the ultrasmall peptide-protected Au nanoclusters are a promising radiosensitizer for cancer radiotherapy. © 2015, Nature Publishing Group. All rights reserved.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/175533
ISSN: 20452322
DOI: 10.1038/srep08669
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