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https://doi.org/10.3390/v7112906
Title: | Genomic mining reveals deep evolutionary relationships between bornaviruses and bats | Authors: | Cui, J Wang, L.-F |
Keywords: | Aedes aegypti Article bat Borna disease virus Bornavirus evolutionary rate genome analysis genomic mining nonhuman phylogeny vesper bat virus transmission animal bat Bornaviridae genetics genomics molecular evolution Animals Bornaviridae Chiroptera Evolution, Molecular Genomics |
Issue Date: | 2015 | Publisher: | MDPI AG | Citation: | Cui, J, Wang, L.-F (2015). Genomic mining reveals deep evolutionary relationships between bornaviruses and bats. Viruses 7 (11) : 5792-5800. ScholarBank@NUS Repository. https://doi.org/10.3390/v7112906 | Abstract: | Bats globally harbor viruses in order Mononegavirales, such as lyssaviruses and henipaviruses; however, little is known about their relationships with bornaviruses. Previous studies showed that viral fossils of bornaviral origin are embedded in the genomes of several mammalian species such as primates, indicative of an ancient origin of exogenous bornaviruses. In this study, we mined the available 10 bat genomes and recreated a clear evolutionary relationship of endogenous bornaviral elements and bats. Comparative genomics showed that endogenization of bornaviral elements frequently occurred in vesper bats, harboring EBLLs (endogenous bornavirus-like L elements) in their genomes. Molecular dating uncovered a continuous bornavirus-bat interaction spanning 70 million years. We conclude that better understanding of modern exogenous bornaviral circulation in bat populations is warranted. © 2015 by the authors; licensee MDPI, Basel, Switzerland. | Source Title: | Viruses | URI: | https://scholarbank.nus.edu.sg/handle/10635/175468 | ISSN: | 19994915 | DOI: | 10.3390/v7112906 |
Appears in Collections: | Staff Publications Elements |
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