Please use this identifier to cite or link to this item: https://doi.org/10.18632/oncotarget.10980
Title: Monocyte-derived factors including PLA2G7 induced by macrophage-nasopharyngeal carcinoma cell interaction promote tumor cell invasiveness
Authors: Low H.B. 
Png C.W. 
Li C. 
Wang D.Y. 
Justin Wong S.B. 
Zhang Y. 
Keywords: connective tissue growth factor
CXCL13 chemokine
gelatinase B
Hermes antigen
interleukin 10
interleukin 1beta
interleukin 6
monocyte chemotactic protein 1
monocyte chemotactic protein 2
transforming growth factor beta
tumor necrosis factor
urokinase
vasculotropin A
1 alkyl 2 acetylglycerophosphocholine esterase
cytokine
PLA2G7 protein, human
Article
carcinoma cell
CCL8 gene
CD44 gene
cell interaction
cell invasion
cell migration
coculture
controlled study
CTGF gene
CXCL13 gene
gene
gene expression
gene induction
human
human cell
IFI gene
IFIT gene
IL 1beta gene
IL 6 gene
macrophage
MCP 1 gene
MMP9 gene
monocyte
nasopharynx carcinoma
OAS gene
PLA2G7 gene
PLAU gene
TNF alpha gene
tumor associated leukocyte
tumor cell
upregulation
VEGFA gene
carcinoma
cell communication
cell motion
genetics
macrophage
metastasis
nasopharynx tumor
pathology
physiology
tumor cell line
tumor invasion
1-Alkyl-2-acetylglycerophosphocholine Esterase
Carcinoma
Cell Communication
Cell Line, Tumor
Cell Movement
Coculture Techniques
Cytokines
Humans
Macrophages
Monocytes
Nasopharyngeal Neoplasms
Neoplasm Invasiveness
Neoplasm Metastasis
Issue Date: 2016
Publisher: Impact Journals LLC
Citation: Low H.B., Png C.W., Li C., Wang D.Y., Justin Wong S.B., Zhang Y. (2016). Monocyte-derived factors including PLA2G7 induced by macrophage-nasopharyngeal carcinoma cell interaction promote tumor cell invasiveness. Oncotarget 7 (34) : 55473-55490. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.10980
Abstract: The non-keratinizing undifferentiated subtype of nasopharyngeal carcinoma (NPC) is a malignancy characterized by an intimate relationship between neoplastic cells and a non-neoplastic lymphoid component. Tumor-associated macrophages (TAMs) foster tumor progression through production of soluble mediators that support proliferation, angiogenesis, survival and invasion of malignant cells. However, the role of macrophages in the progression of NPC remains poorly understood. This study aims to investigate the functional and phenotypic changes that occur to macrophages in macrophage-NPC cell co-culture systems, and how these changes influence tumor cells. We found that monocytes, including THP-1 cells and primary human monocytes, co-cultured with C666-1 NPC cells upregulate expression of pro-inflammatory cytokines at the early stages, followed by the induction of metastasis-related genes and interferon-stimulated genes at the later stage of coculture, indicating that TAMs are "educated" by NPC cells for cancer progression. Importantly, the induction of these factors from the TAMs was also found to enhance the migratory capabilities of the NPC cells. We have also identified one of these macrophage-derived factor, phospholipase A2 Group 7 (PLA2G7), to be important in regulating tumor cell migration and a novel tumor-promoting factor in NPC. Further studies to characterize the role of PLA2G7 in tumor metastasis may help determine its potential as a therapeutic target in NPC.
Source Title: Oncotarget
URI: https://scholarbank.nus.edu.sg/handle/10635/175454
ISSN: 19492553
DOI: 10.18632/oncotarget.10980
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