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|Patient-derived induced pluripotent stem cells and organoids for modeling alpha synuclein propagation in parkinson's disease
transcription factor Sox6
gene delivery system
pluripotent stem cell
|Koh, Y.H, Tan, L.Y, Ng, S.-Y (2018). Patient-derived induced pluripotent stem cells and organoids for modeling alpha synuclein propagation in parkinson's disease. Frontiers in Cellular Neuroscience 12 : 413. ScholarBank@NUS Repository. https://doi.org/10.3389/fncel.2018.00413
|Parkinson's disease (PD) is an age-associated, progressive neurodegenerative disorder characterized by motor impairment and in some cases cognitive decline. Central to the disease pathogenesis of PD is a small, presynaptic neuronal protein known as alpha synuclein (a-syn), which tends to accumulate and aggregate in PD brains as Lewy bodies or Lewy neurites. Numerous in vitro and in vivo studies confirm that a-syn aggregates can be propagated from diseased to healthy cells, and it has been suggested that preventing the spread of pathogenic a-syn species can slow PD progression. In this review, we summarize the works of recent literature elucidating mechanisms of a-syn propagation, and discussed the advantages in using patient-derived induced pluripotent stem cells (iPSCs) and/or induced neurons to study a-syn transmission. © 2018 Koh, Tan and Ng.
|Frontiers in Cellular Neuroscience
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