Please use this identifier to cite or link to this item: https://doi.org/10.3390/antibiotics6030014
Title: Macromolecular conjugate and biological carrier approaches for the targeted delivery of antibiotics
Authors: Tram, N.D.T
Ee, P.L.R 
Keywords: aminoglycoside
ampicillin
antibiotic agent
antigen
chloramphenicol
erythromycin
lincosamide
macrolide
nanocarrier
penicillin derivative
protein
tetracycline
vancomycin
antibacterial activity
antibiotic resistance
antimicrobial activity
Aspergillus fumigatus
atypical Mycobacterium
blood cell
electroporation
erythrocyte
immunogenicity
inflammation
minimum inhibitory concentration
nonhuman
Plasmodium falciparum
priority journal
Pseudomonas aeruginosa
Review
Staphylococcus aureus
Issue Date: 2017
Citation: Tram, N.D.T, Ee, P.L.R (2017). Macromolecular conjugate and biological carrier approaches for the targeted delivery of antibiotics. Antibiotics 6 (3) : 14. ScholarBank@NUS Repository. https://doi.org/10.3390/antibiotics6030014
Abstract: For the past few decades, the rapid rise of antibiotic multidrug-resistance has presented a palpable threat to human health worldwide. Meanwhile, the number of novel antibiotics released to the market has been steadily declining. Therefore, it is imperative that we utilize innovative approaches for the development of antimicrobial therapies. This article will explore alternative strategies, namely drug conjugates and biological carriers for the targeted delivery of antibiotics, which are often eclipsed by their nanomedicine-based counterparts. A variety of macromolecules have been investigated as conjugate carriers, but only those most widely studied in the field of infectious diseases (e.g., proteins, peptides, antibodies) will be discussed in detail. For the latter group, blood cells, especially erythrocytes, have been successfully tested as homing carriers of antimicrobial agents. Bacteriophages have also been studied as a candidate for similar functions. Once these alternative strategies receive the amount of research interest and resources that would more accurately reflect their latent applicability, they will inevitably prove valuable in the perennial fight against antibiotic resistance. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Antibiotics
URI: https://scholarbank.nus.edu.sg/handle/10635/175202
ISSN: 20796382
DOI: 10.3390/antibiotics6030014
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