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Title: Rhythmicity and waves in the cortex of single cells
Authors: Yang, Y 
Wu, M 
Keywords: biological rhythm
wave propagation
biological model
cell differentiation
cell division
Cell Differentiation
Cell Division
Models, Biological
Issue Date: 2018
Publisher: Royal Society Publishing
Citation: Yang, Y, Wu, M (2018). Rhythmicity and waves in the cortex of single cells. Philosophical Transactions of the Royal Society B: Biological Sciences 373 (1747) : 20170116. ScholarBank@NUS Repository.
Abstract: Emergence of dynamic patterns in the form of oscillations and waves on the cortex of single cells is a fascinating and enigmatic phenomenon.Here we outline various theoretical frameworks used to model pattern formation with the goal of reducing complex, heterogeneous patterns into key parameters that are biologically tractable. We also review progress made in recent years on the quantitative and molecular definitions of these terms, which we believe have begun to transform single-cell dynamic patterns from a purely observational and descriptive subject to more mechanistic studies. Specifically, we focus on the nature of local excitable and oscillation events, their spatial coup-lings leading to propagating waves and the role of active membrane. Instead of arguing for their functional importance, we prefer to consider such patterns as basic properties of dynamic systems. We discuss how knowledge of these patterns could be used to dissect the structure of cellular organization and how the network-centric view could help define cellular functions as transitions between different dynamical states. Last, we speculate on how these patterns could encode temporal and spatial information. This article is part of the theme issue ‘Self-organization in cell biology’. © 2018 The Authors.
Source Title: Philosophical Transactions of the Royal Society B: Biological Sciences
ISSN: 0962-8436
DOI: 10.1098/rstb.2017.0116
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