Please use this identifier to cite or link to this item: https://doi.org/10.1186/bcr3678
Title: Breast cancer risk assessment using genetic variants and risk factors in a Singapore Chinese population
Authors: Lee C.P.L.
Irwanto A. 
Salim A.
Yuan J.-M.
Liu J. 
Koh W.P. 
Hartman M. 
Keywords: estrogen
estrogen receptor alpha
estrogen receptor alpha, human
adult
allele
article
blood sampling
body mass
breast cancer
cancer registry
cancer risk
case control study
Chinese
cohort analysis
controlled study
dietary intake
drug use
educational status
family history
female
genetic association
genetic risk
genetic variability
high risk population
human
lifestyle
major clinical study
menarche
menopause
prediction
risk assessment
Singapore
sleep time
aged
Asian continental ancestry group
Breast Neoplasms
gene frequency
genetic predisposition
genetics
middle aged
risk factor
single nucleotide polymorphism
Article
Asian
ESR1 gene
FOXQ1 gene
gene
gene locus
population research
prevalence
sleep
TOX3 gene
Aged
Alleles
Asian Continental Ancestry Group
Body Mass Index
Breast Neoplasms
Case-Control Studies
Estrogen Receptor alpha
Female
Gene Frequency
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Middle Aged
Polymorphism, Single Nucleotide
Risk Factors
Singapore
Issue Date: 2014
Citation: Lee C.P.L., Irwanto A., Salim A., Yuan J.-M., Liu J., Koh W.P., Hartman M. (2014). Breast cancer risk assessment using genetic variants and risk factors in a Singapore Chinese population. Breast Cancer Research 16 (3) : R64. ScholarBank@NUS Repository. https://doi.org/10.1186/bcr3678
Abstract: Introduction: Genetic variants for breast cancer risk identified in genome-wide association studies (GWAS) in Western populations require further testing in Asian populations. A risk assessment model incorporating both validated genetic variants and established risk factors may improve its performance in risk prediction of Asian women.Methods: A nested case-control study of female breast cancer (411 cases and 1,212 controls) within the Singapore Chinese Health Study was conducted to investigate the effects of 51 genetic variants identified in previous GWAS on breast cancer risk. The independent effect of these genetic variants was assessed by creating a summed genetic risk score (GRS) after adjustment for body mass index and the Gail model risk factors for breast cancer.Results: The GRS was an independent predictor of breast cancer risk in Chinese women. The multivariate-adjusted odds ratios (95% confidence intervals) of breast cancer for the second, third, and fourth quartiles of the GRS were 1.26 (0.90 to 1.76), 1.47 (1.06 to 2.04) and 1.75 (1.27 to 2.41) respectively (P for trend <0.001). In addition to established risk factors, the GRS improved the classification of 6.2% of women for their absolute risk of breast cancer in the next five years.Conclusions: Genetic variants on top of conventional risk factors can improve the risk prediction of breast cancer in Chinese women. © 2014 Lee et al.; licensee BioMed Central L
Source Title: Breast Cancer Research
URI: https://scholarbank.nus.edu.sg/handle/10635/174648
ISSN: 1465-5411
DOI: 10.1186/bcr3678
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