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Title: Characterization of chlorhexidine-loaded calcium-hydroxide microparticles as a potential dental pulp-capping material
Authors: Priyadarshini B.M. 
Selvan S.T.
Narayanan K.
Fawzy A.S. 
Issue Date: 2017
Citation: Priyadarshini B.M., Selvan S.T., Narayanan K., Fawzy A.S. (2017). Characterization of chlorhexidine-loaded calcium-hydroxide microparticles as a potential dental pulp-capping material. Bioengineering 4 (3) : 59. ScholarBank@NUS Repository.
Abstract: This study explores the delivery of novel calcium hydroxide [Ca(OH) 2 ] microparticles loaded with chlorhexidine (CHX) for potential dental therapeutic and preventive applications. Herein, we introduce a new approach for drug-delivery to deep dentin-surfaces in the form of drug-loaded microparticles. Unloaded Ca(OH) 2 [Ca(OH) 2 /Blank] and CHX-loaded/Ca(OH) 2 microparticles were fabricated by aqueous chemical-precipitation technique. The synthesized-microparticles were characterized in vitro for determination of surface-morphology, crystalline-features and thermal-properties examined by energy-dispersive X-ray scanning and transmission electron-microscopy (EDX-SEM/TEM), Fourier-transform infrared-spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA) and differential scanning-calorimetry (DSC). Time-related pH changes, initial antibacterial/biofilm-abilities and cytotoxicity of CHX-loaded/Ca(OH) 2 microparticles were evaluated. Microparticles were delivered to dentin-surfaces with subsequent SEM examination of treated dentin-substrates. The in vitro and ex vivo CHX-release profiles were characterized. Ca(OH) 2 /Blank were hexagonal-shaped with highest z-average diameter whereas CHX-inclusion evidenced micro-metric spheres with distinguishable surface “rounded deposits” and a negative-shift in diameter. CHX:Ca(OH) 2 /50 mg exhibited maximum encapsulation-efficiency with good antibacterial and cytocompatible properties. SEM examination revealed an intact layer of microparticles on exposed dentin-surfaces with retention of spherical shape and smooth texture. Microparticles loaded on dentin-surfaces showed prolonged release of CHX indicating substantial retention on dentin-substrates. This study validated the inherent-applicability of this novel drug-delivery approach to dentin-surfaces using micro-metric CHX-loaded/Ca(OH) 2 microparticles. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Bioengineering
ISSN: 2306-5354
DOI: 10.3390/bioengineering4030059
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