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Title: Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population
Authors: Lu Y. 
Tayebi N.
Li H.
Saha N. 
Yang H. 
Heng C.-K. 
Keywords: cholesterol ester transfer protein
high density lipoprotein cholesterol
body mass
cholesterol blood level
coronary artery disease
diabetes mellitus
disease association
gene frequency
genetic association
genetic polymorphism
lipid blood level
major clinical study
population genetics
race difference
sex difference
single nucleotide polymorphism
Case-Control Studies
Cholesterol Ester Transfer Proteins
Cholesterol, HDL
Coronary Artery Disease
Gene Frequency
Genetic Association Studies
Middle Aged
Polymorphism, Genetic
Risk Factors
Sex Characteristics
Issue Date: 2013
Publisher: BioMed Central Ltd.
Citation: Lu Y., Tayebi N., Li H., Saha N., Yang H., Heng C.-K. (2013). Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population. Lipids in Health and Disease 12 (1) : 85. ScholarBank@NUS Repository.
Abstract: Background: Hyperlipidaemia is a major risk factor for coronary artery disease (CAD) and cholesteryl ester transfer protein (CETP) gene polymorphisms are known to be associated with lipid profiles. Methods. In this study, we investigated the association of two polymorphisms in the CETP, Taq1B (rs708272) and -629C > A (rs1800775), with CAD and lipid levels HDL-C in 662 CAD + cases and 927 controls from the Singapore population comprising Chinese, Malays and Indians. Results: TaqB2 frequency was significantly lowest in the Malays (0.43) followed by Chinese (0.47) and highest in the Indians (0.56) in the controls. The B2 allele frequency was significantly lower in the Chinese CAD + cases compared to the controls (p = 0.002). The absence of the B2 allele was associated with CAD with an OR 2.0 (95% CI 1.2 to 3.4) after adjustment for the confounding effects of age, smoking, BMI, gender, hypertension, dyslipidemia and diabetes mellitus. The B2 allele was significantly associated with higher plasma HDL-C levels in the Chinese men after adjusting for confounders. Associations with plasma apoA1 levels were significant only in the Chinese men for Taq1B and -629C > A. In addition, the Taq1B polymorphism was only associated with plasma Apo B and Lp(a) in the Malay men. Significant associations were only found in non-smoking subjects with BMI <50§ssup§th§esup§ percentile. In this study, the LD coefficients between the Taq1B and -629C > A polymorphisms seemed to be weak. Conclusion: The absence the Taq1B2 allele was associated with CAD in the Chinese population only and the minor allele of the Taq1B polymorphism of the CETP gene was significantly associated with higher plasma HDL-C levels in Chinese men. © 2013 Lu et al.; licensee BioMed Central Ltd.
Source Title: Lipids in Health and Disease
ISSN: 1476511X
DOI: 10.1186/1476-511X-12-85
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