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Title: The 5? and 3? untranslated regions of the flaviviral genome
Authors: Ng, W.C 
Soto-Acosta, R
Bradrick, S.S
Garcia-Blanco, M.A 
Ooi, E.E 
Keywords: capped RNA
virus RNA
antibody dependent enhancement
disease carrier
gene mutation
immune response
open reading frame
untranslated region
virus genome
virus replication
3' untranslated region
5' untranslated region
virus replication
3' Untranslated Regions
5' Untranslated Regions
Virus Replication
Issue Date: 2017
Publisher: MDPI AG
Citation: Ng, W.C, Soto-Acosta, R, Bradrick, S.S, Garcia-Blanco, M.A, Ooi, E.E (2017). The 5? and 3? untranslated regions of the flaviviral genome. Viruses 9 (6) : 137. ScholarBank@NUS Repository.
Abstract: Flaviviruses are enveloped arthropod-borne viruses with a single-stranded, positive-sense RNA genome that can cause serious illness in humans and animals. The 11 kb 50 capped RNA genome consists of a single open reading frame (ORF), and is flanked by 50 and 30 untranslated regions (UTR). The ORF is a polyprotein that is processed into three structural and seven non-structural proteins. The UTRs have been shown to be important for viral replication and immune modulation. Both of these regions consist of elements that are essential for genome cyclization, resulting in initiation of RNA synthesis. Genome mutation studies have been employed to investigate each component of the essential elements to show the necessity of each component and its role in viral RNA replication and growth. Furthermore, the highly structured 30UTR is responsible for the generation of subgenomic flavivirus RNA (sfRNA) that helps the virus evade host immune response, thereby affecting viral pathogenesis. In addition, changes within the 30UTR have been shown to affect transmissibility between vector and host, which can influence the development of vaccines. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Viruses
ISSN: 1999-4915
DOI: 10.3390/v9060137
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