Please use this identifier to cite or link to this item: https://doi.org/10.3389/fnagi.2016.00215
Title: Distinct aging effects on functional networks in good and poor cognitive performers
Authors: Lee, A 
Tan, M
Qiu, A 
Keywords: aging
anterior cingulate
cluster analysis
default mode network
functional connectivity
functional magnetic resonance imaging
insula
learning
medial prefrontal cortex
posterior cingulate
rest
salience network
Issue Date: 2016
Publisher: Frontiers Media S.A.
Citation: Lee, A, Tan, M, Qiu, A (2016). Distinct aging effects on functional networks in good and poor cognitive performers. Frontiers in Aging Neuroscience 8 (SEP) : 215. ScholarBank@NUS Repository. https://doi.org/10.3389/fnagi.2016.00215
Abstract: Brain network hubs are susceptible to normal aging processes and disruptions of their functional connectivity are detrimental to decline in cognitive functions in older adults. However, it remains unclear how the functional connectivity of network hubs cope with cognitive heterogeneity in an aging population. This study utilized cognitive and resting-state functional magnetic resonance imaging data, cluster analysis, and graph network analysis to examine age-related alterations in the network hubs' functional connectivity of good and poor cognitive performers. Our results revealed that poor cognitive performers showed age-dependent disruptions in the functional connectivity of the right insula and posterior cingulate cortex (PCC), while good cognitive performers showed age-related disruptions in the functional connectivity of the left insula and PCC. Additionally, the left PCC had age-related declines in the functional connectivity with the left medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC). Most interestingly, good cognitive performers showed age-related declines in the functional connectivity of the left insula and PCC with their right homotopic structures. These results may provide insights of neuronal correlates for understanding individual differences in aging. In particular, our study suggests prominent protection roles of the left insula and PCC and bilateral ACC in good performers. © 2016 Lee, Tan and Qiu.
Source Title: Frontiers in Aging Neuroscience
URI: https://scholarbank.nus.edu.sg/handle/10635/174249
ISSN: 16634365
DOI: 10.3389/fnagi.2016.00215
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