Please use this identifier to cite or link to this item: https://doi.org/10.1155/2010/409320
Title: Boron drug delivery via encapsulated magnetic nanocomposites: A new approach for BNCT in cancer treatment
Authors: Zhu, Y
Lin, Y
Zhu, Y.Z 
Lu, J 
Maguire, J.A
Hosmane, N.S
Keywords: Boron concentrations
Cancer treatment
Carborane cages
Cycloadditions
External magnetic field
Loading amount
Magnetic nanocomposites
Magnetic nanoparticles
New approaches
Normal tissue
Propargyl
Acetylene
Boron
Boron compounds
Drug delivery
Magnetic fields
Magnetic materials
Nanocomposites
Nanoparticles
Tumors
Nanomagnetics
Issue Date: 2010
Citation: Zhu, Y, Lin, Y, Zhu, Y.Z, Lu, J, Maguire, J.A, Hosmane, N.S (2010). Boron drug delivery via encapsulated magnetic nanocomposites: A new approach for BNCT in cancer treatment. Journal of Nanomaterials 2010 : 409320. ScholarBank@NUS Repository. https://doi.org/10.1155/2010/409320
Abstract: Ortho-carborane cages have been successfully attached to modified magnetic nanoparticles via catalytic azide-alkyne cycloadditions between 1-R-2-butyl-Ortho- C2 B10H10 (R = Me, 3; Ph, 4) and propargyl group-enriched magnetic nanoparticles. A loading amount of 9.83mmol boron atom/g starch-matrixed magnetic nanoparticles has been reached. The resulting nanocomposites have been found to be highly tumor-targeted vehicles under the influence of an external magnetic field (1.14T), yielding a high boron concentration of 51.4 ?g/g tumor and ratios of around 10: 1 tumor to normal tissues. Copyright © 2010 Yinghuai Zhu et al.
Source Title: Journal of Nanomaterials
URI: https://scholarbank.nus.edu.sg/handle/10635/174181
ISSN: 16874110
DOI: 10.1155/2010/409320
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