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https://doi.org/10.1155/2010/409320
| Title: | Boron drug delivery via encapsulated magnetic nanocomposites: A new approach for BNCT in cancer treatment | Authors: | Zhu, Y Lin, Y Zhu, Y.Z Lu, J Maguire, J.A Hosmane, N.S |
Keywords: | Boron concentrations Cancer treatment Carborane cages Cycloadditions External magnetic field Loading amount Magnetic nanocomposites Magnetic nanoparticles New approaches Normal tissue Propargyl Acetylene Boron Boron compounds Drug delivery Magnetic fields Magnetic materials Nanocomposites Nanoparticles Tumors Nanomagnetics |
Issue Date: | 2010 | Citation: | Zhu, Y, Lin, Y, Zhu, Y.Z, Lu, J, Maguire, J.A, Hosmane, N.S (2010). Boron drug delivery via encapsulated magnetic nanocomposites: A new approach for BNCT in cancer treatment. Journal of Nanomaterials 2010 : 409320. ScholarBank@NUS Repository. https://doi.org/10.1155/2010/409320 | Abstract: | Ortho-carborane cages have been successfully attached to modified magnetic nanoparticles via catalytic azide-alkyne cycloadditions between 1-R-2-butyl-Ortho- C2 B10H10 (R = Me, 3; Ph, 4) and propargyl group-enriched magnetic nanoparticles. A loading amount of 9.83mmol boron atom/g starch-matrixed magnetic nanoparticles has been reached. The resulting nanocomposites have been found to be highly tumor-targeted vehicles under the influence of an external magnetic field (1.14T), yielding a high boron concentration of 51.4 ?g/g tumor and ratios of around 10: 1 tumor to normal tissues. Copyright © 2010 Yinghuai Zhu et al. | Source Title: | Journal of Nanomaterials | URI: | https://scholarbank.nus.edu.sg/handle/10635/174181 | ISSN: | 16874110 | DOI: | 10.1155/2010/409320 |
| Appears in Collections: | Elements Staff Publications |
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