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https://doi.org/10.1155/2012/870150
| Title: | MicroRnas in neurotoxicity | Authors: | Kaur, P Armugam, A Jeyaseelan, K |
Keywords: | alpha secretase alpha synuclein amyloid beta protein amyloid precursor protein brain derived neurotrophic factor clozapine cocaine dizocilpine DJ 1 protein glutamic acid haloperidol immunoglobulin enhancer binding protein interleukin 1beta leucine rich repeat kinase 2 microRNA morphine n methyl dextro aspartic acid receptor neuropeptide Y nicotine nicotinic receptor blocking agent parkin somatostatin Aicardi Goutieres syndrome alcohol consumption alpha chain amyotrophic lateral sclerosis autism bipolar disorder brain dysfunction brain injury brain ischemia brain tumor cancer patient cell activity cell growth cell migration cell motility chronic pain dementia dentatorubropallidoluysian atrophy drug abuse drug dependence fragile X syndrome frontotemporal dementia gene expression Gilles de la Tourette syndrome glioma hallucination human Huntington disease like syndrome Lewy body motor neuron disease nerve cell plasticity nerve degeneration neurofibrillary tangle neurotoxicity neurotransmission nonhuman Parkinson disease pathophysiology prefrontal cortex prion disease priority journal protein aggregation Rett syndrome review schizophrenia signal transduction traumatic brain injury Williams Beuren syndrome |
Issue Date: | 2012 | Citation: | Kaur, P, Armugam, A, Jeyaseelan, K (2012). MicroRnas in neurotoxicity. Journal of Toxicology 2012 : 870150. ScholarBank@NUS Repository. https://doi.org/10.1155/2012/870150 | Abstract: | MicroRNAs are gaining importance as regulators of gene expression with the capability to fine-tune and modulate cellular events. The complex network with their selective targets (mRNAs/genes) pave way for regulation of many physiological processes. Dysregulation of normal neuronal activities could result in accumulation of substances that are detrimental to neuronal functions and subsequently result in neurotoxicity. Neurotoxicity-mediated pathophysiological conditions could then manifest as diseases or disabilities like Parkinson's and Alzheimer's which have debilitating implications. Such toxicity can be a result of individuals predisposed due to genetic inheritance or from other sources such as brain tumours. Neurotoxicity can also be brought about by external agents like drugs and alcohol as well as brain injury with miRNAs playing a pivotal role in diseases. It is therefore vital to understand the expression of these microRNAs and their impact on neuronal activities. In this paper, we discuss some of the neuronal pathophysiological conditions that could be caused by dysregulated microRNAs. Copyright © 2012 Prameet Kaur et al. | Source Title: | Journal of Toxicology | URI: | https://scholarbank.nus.edu.sg/handle/10635/174177 | ISSN: | 16878191 | DOI: | 10.1155/2012/870150 |
| Appears in Collections: | Elements Staff Publications |
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