Please use this identifier to cite or link to this item: https://doi.org/10.3389/fmicb.2015.01322
Title: Optimizing outcomes in immunocompromised hosts: Understanding the role of immunotherapy in invasive fungal diseases
Authors: Ravikumar, S 
Win, M.S
Chai, L.Y.A 
Keywords: antigen recognition
cell therapy
cell transfer
clinical trial (topic)
cross reaction
fungal virulence
granulocyte transfusion
human
immune response
immunocompromised patient
immunological tolerance
immunoregulation
immunotherapy
mycosis
natural killer cell
nonhuman
protein expression
Review
risk factor
signal transduction
vaccination
Issue Date: 2015
Citation: Ravikumar, S, Win, M.S, Chai, L.Y.A (2015). Optimizing outcomes in immunocompromised hosts: Understanding the role of immunotherapy in invasive fungal diseases. Frontiers in Microbiology 6 (NOV) : 1322. ScholarBank@NUS Repository. https://doi.org/10.3389/fmicb.2015.01322
Abstract: A major global concern is the emergence and spread of systemic life-threatening fungal infections in critically ill patients. The increase in invasive fungal infections, caused most commonly by Candida and Aspergillus species, occurs in patients with impaired defenses due to a number of reasons such as underlying disease, the use of chemotherapeutic and immunosuppressive agents, broad-spectrum antibiotics, prosthetic devices and grafts, burns, neutropenia and HIV infection. The high morbidity and mortality associated with these infections is compounded by the limited therapeutic options and the emergence of drug resistant fungi. Hence, creative approaches to bridge the significant gap in antifungal drug development needs to be explored. Here, we review the potential anti-fungal targets for patient-centered therapies and immune-enhancing strategies for the prevention and treatment of invasive fungal diseases. © 2015 Ravikumar, Win and Chai.
Source Title: Frontiers in Microbiology
URI: https://scholarbank.nus.edu.sg/handle/10635/174131
ISSN: 1664302X
DOI: 10.3389/fmicb.2015.01322
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_3389_fmicb_2015_01322.pdf529.3 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

29
checked on Dec 2, 2021

Page view(s)

109
checked on Dec 2, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.