Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep31652
Title: Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease
Authors: Garcia-Miralles, M
Hong, X
Tan, L.J
Caron, N.S
Huang, Y
To, X.V
Lin, R.Y
Franciosi, S
Papapetropoulos, S
Hayardeny, L
Hayden, M.R 
Chuang, K.-H
Pouladi, M.A 
Keywords: interleukin 6
laquinimod
quinolone derivative
animal
animal behavior
blood
corpus striatum
diffusion tensor imaging
disease model
dose response
drug effect
female
Huntington chorea
male
mouse
pathology
pathophysiology
white matter
Animals
Behavior, Animal
Corpus Striatum
Diffusion Tensor Imaging
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Huntington Disease
Interleukin-6
Male
Mice
Quinolones
White Matter
Issue Date: 2016
Citation: Garcia-Miralles, M, Hong, X, Tan, L.J, Caron, N.S, Huang, Y, To, X.V, Lin, R.Y, Franciosi, S, Papapetropoulos, S, Hayardeny, L, Hayden, M.R, Chuang, K.-H, Pouladi, M.A (2016). Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease. Scientific Reports 6 : 31652. ScholarBank@NUS Repository. https://doi.org/10.1038/srep31652
Abstract: Increasing evidence supports a role for abnormal immune activation and inflammatory responses in Huntington disease (HD). In this study, we evaluated the therapeutic potential of laquinimod (1 and 10 mg/kg), a novel immunomodulatory agent shown to be protective in a number of neuroinflammatory conditions, in the YAC128 mouse model of HD. Treatment with laquinimod for 6 months rescued atrophy in the striatum, in certain cortical regions, and in the corpus callosum of YAC128 HD mice. Diffusion tensor imaging showed that white matter microstructural abnormalities in the posterior corpus callosum were improved following treatment with low dose (1 mg/kg) laquinimod, and were paralleled by reduced levels of interleukin-6 in the periphery of YAC128 HD mice. Functionally, treatment with laquinimod (1 and 10 mg/kg) led to modest improvements in motor function and in depressive-like behaviour. Taken together, these results suggest that laquinimod may improve some features of pathology in HD, and provides support for the role of immune activation in the pathogenesis of HD. © The Author(s) 2016.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/173996
ISSN: 20452322
DOI: 10.1038/srep31652
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