Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep43710
Title: Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells
Authors: Yadavalli, S
Jayaram, S
Manda, S.S
Madugundu, A.K
Nayakanti, D.S
Tan, T.Z 
Bhat, R
Rangarajan, A
Chatterjee, A
Gowda, H
Thiery, J.P 
Kumar, P
Keywords: transcriptome
tumor marker
biology
data mining
epithelial mesenchymal transition
gene expression profiling
gene expression regulation
genetic database
genetics
human
leukocyte
metabolism
molecular genetics
neoplasm
pathology
procedures
signal transduction
tumor cell line
tumor embolism
Biomarkers, Tumor
Cell Line, Tumor
Computational Biology
Data Mining
Databases, Genetic
Epithelial-Mesenchymal Transition
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Leukocytes
Molecular Sequence Annotation
Neoplasms
Neoplastic Cells, Circulating
Signal Transduction
Transcriptome
Issue Date: 2017
Citation: Yadavalli, S, Jayaram, S, Manda, S.S, Madugundu, A.K, Nayakanti, D.S, Tan, T.Z, Bhat, R, Rangarajan, A, Chatterjee, A, Gowda, H, Thiery, J.P, Kumar, P (2017). Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells. Scientific Reports 7 : 43710. ScholarBank@NUS Repository. https://doi.org/10.1038/srep43710
Abstract: Circulating tumor cells (CTCs) play a crucial role in cancer dissemination and provide a promising source of blood-based markers. Understanding the spectrum of transcriptional profiles of CTCs and their corresponding regulatory mechanisms will allow for a more robust analysis of CTC phenotypes. The current challenge in CTC research is the acquisition of useful clinical information from the multitude of high-throughput studies. To gain a deeper understanding of CTC heterogeneity and identify genes, pathways and processes that are consistently affected across tumors, we mined the literature for gene expression profiles in CTCs. Through in silico analysis and the integration of CTC-specific genes, we found highly significant biological mechanisms and regulatory processes acting in CTCs across various cancers, with a particular enrichment of the leukocyte extravasation pathway. This pathway appears to play a pivotal role in the migration of CTCs to distant metastatic sites. We find that CTCs from multiple cancers express both epithelial and mesenchymal markers in varying amounts, which is suggestive of dynamic and hybrid states along the epithelial-mesenchymal transition (EMT) spectrum. Targeting the specific molecular nodes to monitor disease and therapeutic control of CTCs in real time will likely improve the clinical management of cancer progression and metastases. © 2017 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/173936
ISSN: 20452322
DOI: 10.1038/srep43710
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