Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12934-017-0646-4
Title: Cellular factories for coenzyme Q10 production
Authors: Lee, S.Q.E
Tan, T.S
Kawamukai, M
Chen, E.S 
Keywords: 3 hydroxy 3 methylglutaryl coenzyme A
isoprenoid
mevalonic acid
reduced nicotinamide adenine dinucleotide phosphate
s adenosylmethionine
ubidecarenone
antioxidant
ubidecarenone
ubiquinone
vitamin
Agrobacterium tumefaciens
Alzheimer disease
biosynthesis
biotechnological procedures
cardiovascular disease
catalysis
Escherichia coli
fungus
human
Huntington chorea
nonhuman
Parkinson disease
protein structure
Review
Rhodobacter sphaeroides
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sporidiobolus johnsonii
analogs and derivatives
biosynthesis
fermentation
genetics
metabolic engineering
metabolism
microbiology
procedures
protein engineering
Antioxidants
Fermentation
Industrial Microbiology
Metabolic Engineering
Protein Engineering
Saccharomyces cerevisiae
Ubiquinone
Vitamins
Issue Date: 2017
Publisher: BioMed Central Ltd.
Citation: Lee, S.Q.E, Tan, T.S, Kawamukai, M, Chen, E.S (2017). Cellular factories for coenzyme Q10 production. Microbial Cell Factories 16 (1) : 39. ScholarBank@NUS Repository. https://doi.org/10.1186/s12934-017-0646-4
Abstract: Coenzyme Q10 (CoQ10), a benzoquinone present in most organisms, plays an important role in the electron-transport chain, and its deficiency is associated with various neuropathies and muscular disorders. CoQ10 is the only lipid-soluble antioxidant found in humans, and for this, it is gaining popularity in the cosmetic and healthcare industries. To meet the growing demand for CoQ10, there has been considerable interest in ways to enhance its production, the most effective of which remains microbial fermentation. Previous attempts to increase CoQ10 production to an industrial scale have thus far conformed to the strategies used in typical metabolic engineering endeavors. However, the emergence of new tools in the expanding field of synthetic biology has provided a suite of possibilities that extend beyond the traditional modes of metabolic engineering. In this review, we cover the various strategies currently undertaken to upscale CoQ10 production, and discuss some of the potential novel areas for future research. © 2017 The Author(s).
Source Title: Microbial Cell Factories
URI: https://scholarbank.nus.edu.sg/handle/10635/173858
ISSN: 14752859
DOI: 10.1186/s12934-017-0646-4
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