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https://doi.org/10.1126/science.aah6171
Title: | Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion | Authors: | Lees, Joshua A Messa, Mirko Sun, Elizabeth Wen Wheeler, Heather Torta, Federico Wenk, Markus R De Camilli, Pietro Reinisch, Karin M |
Keywords: | Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics BINDING PROTEINS PHOSPHATIDYLSERINE TRANSPORT CALCIUM OSCILLATIONS TULIP SUPERFAMILY SMP DOMAINS EXCHANGE PHOSPHOLIPIDS SITES PHOSPHORYLATION IDENTIFICATION |
Issue Date: | 17-Feb-2017 | Publisher: | AMER ASSOC ADVANCEMENT SCIENCE | Citation: | Lees, Joshua A, Messa, Mirko, Sun, Elizabeth Wen, Wheeler, Heather, Torta, Federico, Wenk, Markus R, De Camilli, Pietro, Reinisch, Karin M (2017-02-17). Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion. SCIENCE 355 (6326). ScholarBank@NUS Repository. https://doi.org/10.1126/science.aah6171 | Abstract: | Copyright 2016 by the American Association for the Advancement of Science; all rights reserved. Insulin is released by β cells in pulses regulated by calcium and phosphoinositide signaling. Here, we describe how transmembrane protein 24 (TMEM24) helps coordinate these signaling events. We showed that TMEM24 is an endoplasmic reticulum (ER)-anchored membrane protein whose reversible localization to ER-plasma membrane (PM) contacts is governed by phosphorylation and dephosphorylation in response to oscillations in cytosolic calcium. A lipid-binding module in TMEM24 transports the phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] precursor phosphatidylinositol between bilayers, allowing replenishment of PI(4,5)P2 hydrolyzed during signaling. In the absence of TMEM24, calcium oscillations are abolished, leading to a defect in triggered insulin release. Our findings implicate direct lipid transport between the ER and the PM in the control of insulin secretion, a process impaired in patients with type II diabetes. | Source Title: | SCIENCE | URI: | https://scholarbank.nus.edu.sg/handle/10635/173253 | ISSN: | 00368075 10959203 |
DOI: | 10.1126/science.aah6171 |
Appears in Collections: | Staff Publications Elements |
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6. Lipid transport by TMEM24 at ER-plasma membrane contacts.pdf | 2.15 MB | Adobe PDF | CLOSED | None |
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