Please use this identifier to cite or link to this item: https://doi.org/10.1080/15592294.2020.1795606
Title: Histone variants in skeletal myogenesis.
Authors: NANDINI KARTHIK 
RESHMA TANEJA 
Keywords: Skeletal myogenesis
epigenetics
histone variants
myopathies
Issue Date: 19-Jul-2020
Publisher: Informa UK Limited
Citation: NANDINI KARTHIK, RESHMA TANEJA (2020-07-19). Histone variants in skeletal myogenesis.. Epigenetics. ScholarBank@NUS Repository. https://doi.org/10.1080/15592294.2020.1795606
Abstract: Histone variants regulate chromatin accessibility and gene transcription. Given their distinct properties and functions, histone variant substitutions allow for profound alteration of nucleosomal architecture and local chromatin landscape. Skeletal myogenesis driven by the key transcription factor MyoD is characterized by precise temporal regulation of myogenic genes. Timed substitution of variants within the nucleosomes provides a powerful means to ensure sequential expression of myogenic genes. Indeed, growing evidence has shown H3.3, H2A.Z, macroH2A and H1b to be critical for skeletal myogenesis. However, the relative importance of various histone variants and their associated chaperones in myogenesis is not fully appreciated. In this review, we summarize the role that histone variants play in altering chromatin landscape to ensure proper muscle differentiation. The temporal regulation and cross talk between histones variants and their chaperones in conjunction with other forms of epigenetic regulation could be critical to understanding myogenesis and their involvement in myopathies.
Source Title: Epigenetics
URI: https://scholarbank.nus.edu.sg/handle/10635/171724
ISSN: 1559-2294
1559-2308
DOI: 10.1080/15592294.2020.1795606
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