Please use this identifier to cite or link to this item: https://doi.org/10.1177/0333102420928079
Title: Infectious and inflammatory disorders might increase the risk of developing idiopathic intracranial hypertension – a national case-control study
Authors: Sundholm, Anna
Burkill, Sarah 
Waldenlind, Elisabet
Bahmanyar, Shahram
Nilsson Remahl, A Ingela M
Issue Date: 29-Apr-2020
Publisher: SAGE Publications
Citation: Sundholm, Anna, Burkill, Sarah, Waldenlind, Elisabet, Bahmanyar, Shahram, Nilsson Remahl, A Ingela M (2020-04-29). Infectious and inflammatory disorders might increase the risk of developing idiopathic intracranial hypertension – a national case-control study. Cephalalgia : 033310242092807-033310242092807. ScholarBank@NUS Repository. https://doi.org/10.1177/0333102420928079
Rights: Attribution 4.0 International
Abstract: Objective To investigate whether conditions causing inflammatory activation are associated with increased risk of idiopathic intracranial hypertension. Methods All newly diagnosed idiopathic intracranial hypertension patients (cases) in Sweden between 2000–2016 were identified using pre-determined algorithms (n = 902) and matched with five controls from the general population and five individuals with an obesity diagnosis (n = 4510) for age, sex, region, and vital status. National health registers provided information on infections, inflammatory disorders and dispensed medications. Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals. Results Compared to general population controls, the cases had fourfold increased odds of having an infection (odds ratio = 4.3, 95% confidence interval 3.3–5.6), and threefold increased odds of an inflammatory disorder the year prior to idiopathic intracranial hypertension diagnosis (odds ratio = 3.2, 95% confidence interval 2.4–4.3). Organ specific analyses showed that odds were increased for the study diseases in the respiratory organ, kidney organ and gastrointestinal tract, but not for female genital infections. Similar results were found when comparing idiopathic intracranial hypertension with obese controls though the odds ratios were of lower magnitude. Sub-analyses on exposure to anti-infectious and anti-inflammatory drugs confirmed the increased odds ratios for idiopathic intracranial hypertension patients. Conclusions These findings suggest that major inflammatory activation may be a risk factor in idiopathic intracranial hypertension development.
Source Title: Cephalalgia
URI: https://scholarbank.nus.edu.sg/handle/10635/170858
ISSN: 03331024
14682982
DOI: 10.1177/0333102420928079
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Cephalalgia 2020.pdfPublished version303.16 kBAdobe PDF

OPEN

PublishedView/Download

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons