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Title: Maternal care in infancy and the course of limbic development
Authors: Lee A 
Poh JS 
Wen DJ 
Tan HM 
Chong YS 
Tan KH 
Gluckman PD 
Fortier MV 
Rifkin-Graboi A
Qiu A 
Keywords: Accelerated development
Maternal sensitivity
Issue Date: 3-Oct-2019
Publisher: Elsevier Ltd
Citation: Lee A, Poh JS, Wen DJ, Tan HM, Chong YS, Tan KH, Gluckman PD, Fortier MV, Rifkin-Graboi A, Qiu A (2019-10-03). Maternal care in infancy and the course of limbic development. Developmental Cognitive Neuroscience 40 : 100714. ScholarBank@NUS Repository.
Abstract: Maternal care may predict limbic development, though relations may vary by age and type of assessment. Here, we examined maternal behavior during early infancy (i.e., six months postpartum) in relation to offspring hippocampal and amygdala volume and microstructure development between 4.5 (n = 99) and 6 (n = 111) years. In interaction with offspring sex, maternal sensitivity predicted left amygdala volume at 6.0 years (?=-0.214, p = 0.032, df = 89) and independently predicted predominately left lateralized aspects of amygdala and hippocampal microstructure at both time points (hippocampus: left FA at 4.5 years [?=-0.241, p = 0.043, df = 68], and, in interaction with sex, left [(? = 0.349, p = 0.022, df = 86) and right FA at 6 years (? = 0.357, p = 0.016, df = 86] and left MD growth [? = -0.517, p = 0.021, df = 37]; amygdala: left MD at 4.5 years [? = -0.319, p = 0.007, df = 69] and, in interaction with offspring sex, left MD growth [? = -0.546, p = 0.019, df = 37]). Results suggest exposure to non-extreme, early insensitive care impacts neuroanatomy important to learning and stress regulation, perhaps by accelerating development. This underscores the need to promote sensitive caregiving during early infancy within community samples. © 2019 The Author(s)
Source Title: Developmental Cognitive Neuroscience
ISSN: 18789293
DOI: 10.1016/j.dcn.2019.100714
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