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Title: IL-37: An anti-inflammatory cytokine with antitumor functions
Authors: Yu Mei 
Haiyan Liu 
Issue Date: 1-Apr-2019
Publisher: Wiley
Citation: Yu Mei, Haiyan Liu (2019-04-01). IL-37: An anti-inflammatory cytokine with antitumor functions. Cancer Reports 2 (2) : e1151-e1151. ScholarBank@NUS Repository.
Abstract: © 2018 Wiley Periodicals, Inc. Background: IL-37 is a newly identified IL-1 family cytokine. Unlike other members in IL-1 family, IL-37 has been demonstrated to be an anti-inflammatory cytokine in many inflammatory and autoimmune diseases. IL-37 is regarded as a dual-function cytokine as both the extracellular and intracellular IL-37 are biologically functional. Extracellular IL-37 can bind to IL-18Rα and IL-1R8 to form a triple complex, regulating the downstream STAT3 and PTEN signaling. Intracellular IL-37 can interact with Smad3, translocate into nucleus, and regulate downstream target gene expressions. Recently, the role of IL-37 in tumor development has been extensively studied. Recent findings: IL-37 has been found to play an antitumor role in various types of tumors, such as non-small cell lung cancer, hepatocellular carcinoma, and renal cell carcinoma. Many mechanism studies have been carried out to elaborate the possible effects of IL-37 on tumor growth, immune responses, and tumor angiogenesis. More importantly, the function of IL-37 may be dependent on its concentration and receptor expression. It can form dimers at high concentrations to be inactivated, thus inhibiting its anti-inflammatory function. We focused on the role of IL-37 in various tumor types and provided the hypothesis regarding the underlying mechanisms. Conclusion: IL-37 may affect tumor development through multiple mechanisms: (1) IL-37 directly influences tumor cell viability; (2) IL-37 regulates the immune response to promote the antitumor immunity; and (3) IL-37 suppresses tumor angiogenesis in the tumor microenvironment. Future studies are warranted to further investigate the mechanisms of these multifaceted functions of IL-37 in animal models and cancer patients.
Source Title: Cancer Reports
ISSN: 2573-8348
DOI: 10.1002/cnr2.1151
Appears in Collections:Staff Publications

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